An update on mortality in systemic lupus erythematosus

Anthony Ippolito, Michelle Petri

Research output: Contribution to journalReview articlepeer-review


Objective. Both systemic lupus erythematosus (SLE) and its treatments can contribute to increased mortality rates. The main focus of this review is recent studies on mortality during the last 5 years. Methods. A literature search using PUBMED was performed for articles relating to lupus mortality with a specific focus on literature published within the last 5 years. Results. Survival rates for lupus patients have improved greatly with the ability to treat disease-specific manifestations and infections and to lessen the impact of comorbid conditions. Nonetheless, disparities in mortality rates still exist based on ethnicity, socioeconomic status, age, and gender. Cardiovascular disease, infection, and severe disease activity remain common causes of mortality. Conclusions. Despite advances in the treatment of SLE-associated infection, and renal failure, increased mortality remains a major concern in patient management.

Original languageEnglish (US)
Pages (from-to)S72-S79
JournalClinical and experimental rheumatology
Issue number5 SUPPL. 51
StatePublished - Sep 2008


  • Coronary artery disease
  • Infection
  • Malignancy
  • Morbidity
  • Mortality
  • Renal disease
  • SLE
  • Socioeconomic factors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology


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