An update on approaches to the development of respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) vaccines

Brian R. Murphy, Susan L. Hall, Arun B. Kulkarni, James E. Crowe, Peter L. Collins, Mark Connors, Ruth A. Karron, Robert M. Chanock

Research output: Contribution to journalArticle

Abstract

RSV and PIV3 are responsible for about 30% of severe viral respiratory tract disease leading to hospitilization of infants and children. For this reason, there is a need to develop vaccines effective against these viruses. Since these viruses cause severe disease in early infancy, vaccines must be effective in the presence of maternal antibody. Currently, several strategies for immunization against these viruses are being explored including peptide vaccines, subunit vaccines, vectored vaccines (e.g., vaccinia-RSV or adenovirus-RSV recombinants), and live attenuated virus vaccines. The current status of these approaches is reviewed. In addition, the immunologic basis for the disease potentiation seen in vaccinees immunized with formalin-inactivated RSV during subsequent RSV infection is reviewed. The efficacy of immunization in the presence of maternal antibody is discussed. Much progress for a RSV and PIV3 vaccine has been made and successful immunization against each of these pathogens should be achieved within this decade.

Original languageEnglish (US)
Pages (from-to)13-36
Number of pages24
JournalVirus Research
Volume32
Issue number1
DOIs
StatePublished - Apr 1994

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ASJC Scopus subject areas

  • Cancer Research
  • Virology
  • Infectious Diseases

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