An Unusual Outbreak of Brucellosis

Kenrad Edwin Nelson, Frederick L. Ruben, Burton Andersen

Research output: Contribution to journalArticle

Abstract

A Brucella melitensis infection involved three persons. The infections were acquired by contact with a culture suspension that had been spilled during a laboratory exercise. One of the patients had only indirect contact with the spilled culture, probably contact with contaminated fomites. Another of the patients developed a clinical remission before treatment with antibiotics and relapsed after six months. This patient also had a positive bone marrow culture when blood cultures were negative. The type of antibody response persisting in the sera of convalescents was studied by treating the sera with mercaptoethanol and rabbit antihuman IgM sera. In the patient who relapsed, IgG antibody predominated, whereas IgM persisted for over two years in the patient without relapsing disease.

Original languageEnglish (US)
Pages (from-to)691-695
Number of pages5
JournalArchives of Internal Medicine
Volume135
Issue number5
DOIs
StatePublished - 1975
Externally publishedYes

Fingerprint

Brucellosis
Disease Outbreaks
Immunoglobulin M
Fomites
Serum
Brucella melitensis
Mercaptoethanol
Infection
Antibody Formation
Suspensions
Immunoglobulin G
Bone Marrow
Exercise
Anti-Bacterial Agents
Rabbits
Antibodies

ASJC Scopus subject areas

  • Internal Medicine

Cite this

An Unusual Outbreak of Brucellosis. / Nelson, Kenrad Edwin; Ruben, Frederick L.; Andersen, Burton.

In: Archives of Internal Medicine, Vol. 135, No. 5, 1975, p. 691-695.

Research output: Contribution to journalArticle

Nelson, Kenrad Edwin ; Ruben, Frederick L. ; Andersen, Burton. / An Unusual Outbreak of Brucellosis. In: Archives of Internal Medicine. 1975 ; Vol. 135, No. 5. pp. 691-695.
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