An unusual karyotype in leiomyoma: Case report and literature review

Le Chang, Nagesh Rao, Nicholas Bernthal, Sarah M. Dry, Aaron W. James

Research output: Contribution to journalArticlepeer-review


Vascular leiomyoma are uncommon, clinically benign smooth muscle tumors. Here we report a case of an otherwise typical leiomyoma with unusual cytogenetic changes including t(1;10). Reports from the existing literature suggest that approximately 40-50% of leiomyo- mas contain nonrandom chromosomal abnormalities of which a subset is tumor specific. t(12;14)(q15;q24) is one of the most common translocations, which occur in approximately 20% of karyotypes. Additional aberrations include del(7)(q22-q32), trisomy 12, and 6p21 rearrangements. Other recurrent abnormalities include monosomy 22, monosomy 10, del (10q), and structural rearrangements of chromosome 3.

Original languageEnglish (US)
Pages (from-to)S251-S254
JournalJournal of Orthopaedics
StatePublished - 2015
Externally publishedYes


  • Leiomyoma
  • Leiomyosarcoma
  • Smooth muscle tumors
  • t(1 ;10)

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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