An unusual complex karyotype in myopericytoma

Aaron W. James, Le Chang, Swati Shrestha, Carlos A. Tirado, Sarah M. Dry

Research output: Contribution to journalArticlepeer-review


Introduction: Myopericytoma is a perivascular neoplasm commonly found in the skin and soft tissue of extremities. These lesions often exhibit concentric vascular proliferation of spindle shaped myoid cells. Methods/Results: We present a case of a 76-year old male who was diagnosed with myopericytoma and subsequent cytogenetic analysis found a highly abnormal karyotype. This karyotype includes cytogenetic mutations that have not been described in previous case studies of myopericytoma. Conclusions: Some of these aberrations occur on genes that are involved in hedgehog signaling as well as pericyte proliferation, indicating a potential pericyte origin for myopericytoma tumors.

Original languageEnglish (US)
Pages (from-to)58-62
Number of pages5
JournalJournal of Orthopaedics
Issue number1
StatePublished - Mar 1 2015
Externally publishedYes


  • Complex karyotype
  • Myopericytoma
  • Pericyte
  • Perivascular tumor

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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