An unusual complex karyotype in myopericytoma

Aaron James, Le Chang, Swati Shrestha, Carlos A. Tirado, Sarah M. Dry

Research output: Contribution to journalArticle

Abstract

Introduction: Myopericytoma is a perivascular neoplasm commonly found in the skin and soft tissue of extremities. These lesions often exhibit concentric vascular proliferation of spindle shaped myoid cells. Methods/Results: We present a case of a 76-year old male who was diagnosed with myopericytoma and subsequent cytogenetic analysis found a highly abnormal karyotype. This karyotype includes cytogenetic mutations that have not been described in previous case studies of myopericytoma. Conclusions: Some of these aberrations occur on genes that are involved in hedgehog signaling as well as pericyte proliferation, indicating a potential pericyte origin for myopericytoma tumors.

Original languageEnglish (US)
Pages (from-to)58-62
Number of pages5
JournalJournal of Orthopaedics
Volume12
Issue number1
DOIs
StatePublished - Mar 1 2015
Externally publishedYes

Fingerprint

Pericytes
Karyotype
Abnormal Karyotype
Cytogenetic Analysis
Cytogenetics
Blood Vessels
Neoplasms
Extremities
Skin
Mutation
Genes

Keywords

  • Complex karyotype
  • Myopericytoma
  • Pericyte
  • Perivascular tumor

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

James, A., Chang, L., Shrestha, S., Tirado, C. A., & Dry, S. M. (2015). An unusual complex karyotype in myopericytoma. Journal of Orthopaedics, 12(1), 58-62. https://doi.org/10.1016/j.jor.2015.01.015

An unusual complex karyotype in myopericytoma. / James, Aaron; Chang, Le; Shrestha, Swati; Tirado, Carlos A.; Dry, Sarah M.

In: Journal of Orthopaedics, Vol. 12, No. 1, 01.03.2015, p. 58-62.

Research output: Contribution to journalArticle

James, A, Chang, L, Shrestha, S, Tirado, CA & Dry, SM 2015, 'An unusual complex karyotype in myopericytoma', Journal of Orthopaedics, vol. 12, no. 1, pp. 58-62. https://doi.org/10.1016/j.jor.2015.01.015
James, Aaron ; Chang, Le ; Shrestha, Swati ; Tirado, Carlos A. ; Dry, Sarah M. / An unusual complex karyotype in myopericytoma. In: Journal of Orthopaedics. 2015 ; Vol. 12, No. 1. pp. 58-62.
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