An unusual case of bowel perforation

Roxana Elena Lazarescu, Kelley Bohm

Research output: Contribution to journalArticlepeer-review


Bowel perforation is a potentially fatal complication of obstruction, ischaemia, trauma, surgery and medications. It is recognised by clinical suspicion based on history, symptoms of severe abdominal pain and signs such as rebound tenderness, as well as imaging showing free air in the abdomen. Bevacizumab (aka avastin) is an antineoplastic recombinant monoclonal antibody that inhibits angiogenesis in a variety of malignancies. Colonic perforation is a recognised but rare complication of this therapy, likely due to aforementioned bowel ischaemia or compromised mucosal microcirculation which increases susceptibility to injury. We are presenting a case of an unrecognised bowel perforation caused in a patient with abdominal carcinomatosis.

Original languageEnglish (US)
Article number1437
JournalBMJ case reports
StatePublished - Jun 23 2014
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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