An unstable nuclear matrix may contribute to genetic instability

Kenneth Pienta, W. S. Ward

Research output: Contribution to journalArticle

Abstract

Cancer cells proliferate and metastasize against the body's defense mechanisms due to their ability to change in response to challenges, both from the body's internal defenses as well as those from external sources, such as radiation and chemotherapy. This ability of tumor cell populations to change and grow in response to these stresses as well as to hold populations of cells with diverse abilitites has been termed 'tumor cell heterogeneity'. Tumor cell heterogeneity is thought to arise in cancer cell populations as a result of genetic instability, an undefined process by which the genetic material of the cell is rendered more labile and more likely to undergo changes in structure, conformation, and function. DNA is structurally and functionally organized by the nuclear matrix, the dynamic RNA-protein skeleton of the nucleus. We provide here a proposal that provides a framework for understanding genetic instability in terms of an unstable nuclear matrix.

Original languageEnglish (US)
Pages (from-to)45-52
Number of pages8
JournalMedical Hypotheses
Volume42
Issue number1
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Nuclear Matrix
Neoplasms
Population
Skeleton
RNA
Radiation
Drug Therapy
DNA

ASJC Scopus subject areas

  • Developmental Biology
  • Medicine(all)
  • Drug Discovery

Cite this

An unstable nuclear matrix may contribute to genetic instability. / Pienta, Kenneth; Ward, W. S.

In: Medical Hypotheses, Vol. 42, No. 1, 1994, p. 45-52.

Research output: Contribution to journalArticle

@article{07c79e9e204d44adb045a8cb3d6a8cb9,
title = "An unstable nuclear matrix may contribute to genetic instability",
abstract = "Cancer cells proliferate and metastasize against the body's defense mechanisms due to their ability to change in response to challenges, both from the body's internal defenses as well as those from external sources, such as radiation and chemotherapy. This ability of tumor cell populations to change and grow in response to these stresses as well as to hold populations of cells with diverse abilitites has been termed 'tumor cell heterogeneity'. Tumor cell heterogeneity is thought to arise in cancer cell populations as a result of genetic instability, an undefined process by which the genetic material of the cell is rendered more labile and more likely to undergo changes in structure, conformation, and function. DNA is structurally and functionally organized by the nuclear matrix, the dynamic RNA-protein skeleton of the nucleus. We provide here a proposal that provides a framework for understanding genetic instability in terms of an unstable nuclear matrix.",
author = "Kenneth Pienta and Ward, {W. S.}",
year = "1994",
doi = "10.1016/0306-9877(94)90035-3",
language = "English (US)",
volume = "42",
pages = "45--52",
journal = "Medical Hypotheses",
issn = "0306-9877",
publisher = "Churchill Livingstone",
number = "1",

}

TY - JOUR

T1 - An unstable nuclear matrix may contribute to genetic instability

AU - Pienta, Kenneth

AU - Ward, W. S.

PY - 1994

Y1 - 1994

N2 - Cancer cells proliferate and metastasize against the body's defense mechanisms due to their ability to change in response to challenges, both from the body's internal defenses as well as those from external sources, such as radiation and chemotherapy. This ability of tumor cell populations to change and grow in response to these stresses as well as to hold populations of cells with diverse abilitites has been termed 'tumor cell heterogeneity'. Tumor cell heterogeneity is thought to arise in cancer cell populations as a result of genetic instability, an undefined process by which the genetic material of the cell is rendered more labile and more likely to undergo changes in structure, conformation, and function. DNA is structurally and functionally organized by the nuclear matrix, the dynamic RNA-protein skeleton of the nucleus. We provide here a proposal that provides a framework for understanding genetic instability in terms of an unstable nuclear matrix.

AB - Cancer cells proliferate and metastasize against the body's defense mechanisms due to their ability to change in response to challenges, both from the body's internal defenses as well as those from external sources, such as radiation and chemotherapy. This ability of tumor cell populations to change and grow in response to these stresses as well as to hold populations of cells with diverse abilitites has been termed 'tumor cell heterogeneity'. Tumor cell heterogeneity is thought to arise in cancer cell populations as a result of genetic instability, an undefined process by which the genetic material of the cell is rendered more labile and more likely to undergo changes in structure, conformation, and function. DNA is structurally and functionally organized by the nuclear matrix, the dynamic RNA-protein skeleton of the nucleus. We provide here a proposal that provides a framework for understanding genetic instability in terms of an unstable nuclear matrix.

UR - http://www.scopus.com/inward/record.url?scp=0028349466&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028349466&partnerID=8YFLogxK

U2 - 10.1016/0306-9877(94)90035-3

DO - 10.1016/0306-9877(94)90035-3

M3 - Article

C2 - 8196560

AN - SCOPUS:0028349466

VL - 42

SP - 45

EP - 52

JO - Medical Hypotheses

JF - Medical Hypotheses

SN - 0306-9877

IS - 1

ER -