TY - JOUR
T1 - An ultrastructural study of the corpora amylacea of the optic nerve head and retina
AU - Woodford, B.
AU - Tso, M. O.M.
N1 - Funding Information:
In an ultrastructural study of the brain tissue in a single human case, Ramsey! interpreted corpora amylacea as being glial in nature. Blackwood and Corsellis.! Yanoff and Fine.! and Avendano and associates! concurred that corpora amylacea are astrocytic. Anzil and colleagues? examined the brains from aged patients and claimed to see corpora amylacea inside astrocytic processes and also observed them within neuronal processes on rare occasions. Takahashi, Iwata, and Nakamura! noted that corpora amylacea are "intra-axonal" in the central nervous From the Georgiana Theobald Ophthalmic Pathology Laboratory, Department of Ophthalmology, University ofIllinois, EyeandEarInfirmary, Chicago, Illinois. This investigation was supported in part by grants EY01903, EYOl904, EY703802, and 1P30EY01792 from the Public Health Service. Dr. Tso is a Research to Prevent Blindness-William Friedkin Scholar. Reprint request to Mark Tso, M. D., Department ofOphthalmology, University ofIllinois EyeandEar Infirmary, 1855 W. Taylor St., Chicago, IL 60612.
PY - 1980
Y1 - 1980
N2 - We studied corpora amylacea in the optic nerve heads and retinas of four human eyes with increased intraocular pressure by light and electron microscopy. Ultrastructurally they consisted of a mass of filamentous tangle discretely bordered by normal or abnormal axoplasm within an axonal swelling. We found neurotubules, mitochondria, and the accumulation of dense bodies in the axoplasm surrounding the filamentous tangle. We noted ultrastructural similarities between corpora amylacea and cytoid bodies, swollen axons with transport block, and experimentally induced neurofibrillary tangles. We concluded that corpora amylacea are intracellular organelles found in axonal swellings and are not glial in origin, as previously believed. There is a possible relationship between corpora amylacea and disturbance of axoplasmic transport.
AB - We studied corpora amylacea in the optic nerve heads and retinas of four human eyes with increased intraocular pressure by light and electron microscopy. Ultrastructurally they consisted of a mass of filamentous tangle discretely bordered by normal or abnormal axoplasm within an axonal swelling. We found neurotubules, mitochondria, and the accumulation of dense bodies in the axoplasm surrounding the filamentous tangle. We noted ultrastructural similarities between corpora amylacea and cytoid bodies, swollen axons with transport block, and experimentally induced neurofibrillary tangles. We concluded that corpora amylacea are intracellular organelles found in axonal swellings and are not glial in origin, as previously believed. There is a possible relationship between corpora amylacea and disturbance of axoplasmic transport.
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U2 - 10.1016/S0002-9394(14)75018-4
DO - 10.1016/S0002-9394(14)75018-4
M3 - Article
C2 - 7424747
AN - SCOPUS:0018938560
SN - 0002-9394
VL - 90
SP - 492
EP - 502
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 4
ER -