Abstract
The perifollicular capillaries of the rabbit ovary were observed by light and electron microscopy following administration of human chorionic gonadotropin (hCG) and indomethacin (IM). Fenestrations and interendothelial gaps were not observed at 4, 10, or 12 hours, at which times carbon particles were confined to capillary lumina. By 24 hours, dilated capillaries were noted among granulosa cells and theca. In the theca, interendothelial gaps permeable to carbon particles were observed. At 48 hours, ribosome-rich, newly developed capillaries were noted. Many collagen fibrils were observed in the tunica albuginea and theca externa in hCG/IM-treated rabbits in contrast to those treated with hCG alone. Ovarian prostaglandins normally produced in response to gonadotropins may be responsible for alterations in perifollicular capillaries and degradation of collagen in the follicular wall, changes considered essential for ovulation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 85-92 |
| Number of pages | 8 |
| Journal | Fertility and Sterility |
| Volume | 39 |
| Issue number | 1 |
| State | Published - 1983 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
An ultrastructural study of ovarian perifollicular capillaries in the indomethacin-treated rabbit. / Okuda, Y.; Okamura, H.; Kanzaki, H.; Fujii, S.; Takenaka, A.; Wallach, Edward E.
In: Fertility and Sterility, Vol. 39, No. 1, 1983, p. 85-92.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An ultrastructural study of ovarian perifollicular capillaries in the indomethacin-treated rabbit
AU - Okuda, Y.
AU - Okamura, H.
AU - Kanzaki, H.
AU - Fujii, S.
AU - Takenaka, A.
AU - Wallach, Edward E
PY - 1983
Y1 - 1983
N2 - The perifollicular capillaries of the rabbit ovary were observed by light and electron microscopy following administration of human chorionic gonadotropin (hCG) and indomethacin (IM). Fenestrations and interendothelial gaps were not observed at 4, 10, or 12 hours, at which times carbon particles were confined to capillary lumina. By 24 hours, dilated capillaries were noted among granulosa cells and theca. In the theca, interendothelial gaps permeable to carbon particles were observed. At 48 hours, ribosome-rich, newly developed capillaries were noted. Many collagen fibrils were observed in the tunica albuginea and theca externa in hCG/IM-treated rabbits in contrast to those treated with hCG alone. Ovarian prostaglandins normally produced in response to gonadotropins may be responsible for alterations in perifollicular capillaries and degradation of collagen in the follicular wall, changes considered essential for ovulation.
AB - The perifollicular capillaries of the rabbit ovary were observed by light and electron microscopy following administration of human chorionic gonadotropin (hCG) and indomethacin (IM). Fenestrations and interendothelial gaps were not observed at 4, 10, or 12 hours, at which times carbon particles were confined to capillary lumina. By 24 hours, dilated capillaries were noted among granulosa cells and theca. In the theca, interendothelial gaps permeable to carbon particles were observed. At 48 hours, ribosome-rich, newly developed capillaries were noted. Many collagen fibrils were observed in the tunica albuginea and theca externa in hCG/IM-treated rabbits in contrast to those treated with hCG alone. Ovarian prostaglandins normally produced in response to gonadotropins may be responsible for alterations in perifollicular capillaries and degradation of collagen in the follicular wall, changes considered essential for ovulation.
UR - http://www.scopus.com/inward/record.url?scp=0020666686&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020666686&partnerID=8YFLogxK
M3 - Article
C2 - 6848395
AN - SCOPUS:0020666686
VL - 39
SP - 85
EP - 92
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 1
ER -