An ultrastructural study of ovarian perifollicular capillaries in the indomethacin-treated rabbit

Y. Okuda, H. Okamura, H. Kanzaki, S. Fujii, A. Takenaka, Edward E Wallach

Research output: Contribution to journalArticle


The perifollicular capillaries of the rabbit ovary were observed by light and electron microscopy following administration of human chorionic gonadotropin (hCG) and indomethacin (IM). Fenestrations and interendothelial gaps were not observed at 4, 10, or 12 hours, at which times carbon particles were confined to capillary lumina. By 24 hours, dilated capillaries were noted among granulosa cells and theca. In the theca, interendothelial gaps permeable to carbon particles were observed. At 48 hours, ribosome-rich, newly developed capillaries were noted. Many collagen fibrils were observed in the tunica albuginea and theca externa in hCG/IM-treated rabbits in contrast to those treated with hCG alone. Ovarian prostaglandins normally produced in response to gonadotropins may be responsible for alterations in perifollicular capillaries and degradation of collagen in the follicular wall, changes considered essential for ovulation.

Original languageEnglish (US)
Pages (from-to)85-92
Number of pages8
JournalFertility and Sterility
Issue number1
Publication statusPublished - 1983
Externally publishedYes


ASJC Scopus subject areas

  • Obstetrics and Gynecology

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