An ultrastructural analysis of human post-infectious (allergic) encephalomyelitis

P. A. Calabresi, J. M. Powers

Research output: Contribution to journalArticlepeer-review

Abstract

A 6-year-old boy developed post-infectious encephalomyelitis and underwent a brain biopsy (10 days after the onset of neurologic symptoms). Electron microscopic analysis of brain showed demyelinated axons, thinly myelinated axons, aberrant remyelination, and numerous phagocytes containing myelin debris. Physical stripping of myeling by pseudopodial extensions of macrophages, as reported in experimental allergic encephalomyelitis, was noted. Hypertrophic and hyperplastic astrocytes were prominent among the phagocytic cells and played an unexpectedly active role in demyelination.

Original languageEnglish (US)
Pages (from-to)541-544
Number of pages4
JournalActa neuropathologica
Volume87
Issue number5
DOIs
StatePublished - May 1 1994
Externally publishedYes

Keywords

  • Allergic Encephalomyelitis
  • Astrocytes
  • Demyelination
  • Electron microscopy
  • Multiple sclerosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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