An ultrastructural analysis of human post-infectious (allergic) encephalomyelitis

P. A. Calabresi; J. M. Powers

doi:10.1007/BF00294183

An ultrastructural analysis of human post-infectious (allergic) encephalomyelitis

P. A. Calabresi, J. M. Powers

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A 6-year-old boy developed post-infectious encephalomyelitis and underwent a brain biopsy (10 days after the onset of neurologic symptoms). Electron microscopic analysis of brain showed demyelinated axons, thinly myelinated axons, aberrant remyelination, and numerous phagocytes containing myelin debris. Physical stripping of myeling by pseudopodial extensions of macrophages, as reported in experimental allergic encephalomyelitis, was noted. Hypertrophic and hyperplastic astrocytes were prominent among the phagocytic cells and played an unexpectedly active role in demyelination.

Original language	English (US)
Pages (from-to)	541-544
Number of pages	4
Journal	Acta neuropathologica
Volume	87
Issue number	5
DOIs	https://doi.org/10.1007/BF00294183
State	Published - May 1994
Externally published	Yes

Keywords

Allergic Encephalomyelitis
Astrocytes
Demyelination
Electron microscopy
Multiple sclerosis

ASJC Scopus subject areas

Pathology and Forensic Medicine
Clinical Neurology
Cellular and Molecular Neuroscience

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10.1007/BF00294183

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abstract = "A 6-year-old boy developed post-infectious encephalomyelitis and underwent a brain biopsy (10 days after the onset of neurologic symptoms). Electron microscopic analysis of brain showed demyelinated axons, thinly myelinated axons, aberrant remyelination, and numerous phagocytes containing myelin debris. Physical stripping of myeling by pseudopodial extensions of macrophages, as reported in experimental allergic encephalomyelitis, was noted. Hypertrophic and hyperplastic astrocytes were prominent among the phagocytic cells and played an unexpectedly active role in demyelination.",

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AB - A 6-year-old boy developed post-infectious encephalomyelitis and underwent a brain biopsy (10 days after the onset of neurologic symptoms). Electron microscopic analysis of brain showed demyelinated axons, thinly myelinated axons, aberrant remyelination, and numerous phagocytes containing myelin debris. Physical stripping of myeling by pseudopodial extensions of macrophages, as reported in experimental allergic encephalomyelitis, was noted. Hypertrophic and hyperplastic astrocytes were prominent among the phagocytic cells and played an unexpectedly active role in demyelination.

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KW - Astrocytes

KW - Demyelination

KW - Electron microscopy

KW - Multiple sclerosis

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An ultrastructural analysis of human post-infectious (allergic) encephalomyelitis

Abstract

Keywords

ASJC Scopus subject areas

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