An ultrasensitive transducer for measurement of isometric contractile force from single heart cells

Research output: Contribution to journalArticlepeer-review

Abstract

A novel ultrasensitive force transducer suitable for measuring isometric forces generated by single spindleshaped muscle cells is described. The transducer components are mechanically and electrically simple, consisting of a low power He-Ne laser, a pair of step index, glass optic fibers, and a photodiode detector circuit. To test the operation of the transducer, enzymatically isolated frog ventricular heart cells were used, having peak contractile forces on the order of 100 nN. The transducer presents a number of advantages over existing designs and has a resolution better than 2 nN. As such, it is suitable for excitation-contraction studies in single muscle cells.

Original languageEnglish (US)
Pages (from-to)109-115
Number of pages7
JournalPflügers Archiv European Journal of Physiology
Volume407
Issue number1
DOIs
StatePublished - Jul 1986
Externally publishedYes

Keywords

  • Force transducer
  • Isometric tension
  • Muscle mechanics
  • Muscle transducer
  • Single heart cell
  • Tension transducer

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

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