An oxytocin-induced facilitation of neural and emotional responses to social touch correlates inversely with autism traits

Dirk Scheele, Keith M. Kendrick, Christoph Khouri, Elisa Kretzer, Thomas E. Schlaepfer, Birgit Stoffel-Wagner, Onur Güntürkün, Wolfgang Maier, René Hurlemann

Research output: Contribution to journalArticle

Abstract

Social communication through touch and mutual grooming can convey highly salient socio-emotional signals and has been shown to involve the neuropeptide oxytocin (OXT) in several species. Less is known about the modulatory influence of OXT on the neural and emotional responses to human interpersonal touch. The present randomized placebo (PLC)-controlled within-subject pharmaco-functional magnetic resonance imaging (fMRI) study was designed to test the hypothesis that a single intranasal dose of synthetic OXT (24 IU) would facilitate both neural and emotional responses to interpersonal touch in a context- (female vs male touch) and trait- (autistic trait load) specific manner. Specifically, the experimental rationale was to manipulate the reward value of interpersonal touch independent of the intensity and type of actual cutaneous stimulation administered. Thus, 40 heterosexual males believed that they were touched by either a man or a woman, although in fact an identical pattern of touch was always given by the same female experimenter blind to condition type. Our results show that OXT increased the perceived pleasantness of female, but not male touch, and associated neural responses in insula, precuneus, orbitofrontal, and pregenual anterior cingulate cortex. Moreover, the behavioral and neural effects of OXT were negatively correlated with autistic-like traits. Taken together, this is the first study to show that the perceived hedonic value of human heterosexual interpersonal touch is facilitated by OXT in men, but that its behavioral and neural effects in this context are blunted in individuals with autistic traits.

Original languageEnglish (US)
Pages (from-to)2078-2085
Number of pages8
JournalNeuropsychopharmacology
Volume39
Issue number9
DOIs
StatePublished - 2014

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Touch
Oxytocin
Autistic Disorder
Heterosexuality
Grooming
Parietal Lobe
Pleasure
Gyrus Cinguli
Neuropeptides
Reward
Communication
Placebos
Magnetic Resonance Imaging
Skin

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Medicine(all)

Cite this

An oxytocin-induced facilitation of neural and emotional responses to social touch correlates inversely with autism traits. / Scheele, Dirk; Kendrick, Keith M.; Khouri, Christoph; Kretzer, Elisa; Schlaepfer, Thomas E.; Stoffel-Wagner, Birgit; Güntürkün, Onur; Maier, Wolfgang; Hurlemann, René.

In: Neuropsychopharmacology, Vol. 39, No. 9, 2014, p. 2078-2085.

Research output: Contribution to journalArticle

Scheele, D, Kendrick, KM, Khouri, C, Kretzer, E, Schlaepfer, TE, Stoffel-Wagner, B, Güntürkün, O, Maier, W & Hurlemann, R 2014, 'An oxytocin-induced facilitation of neural and emotional responses to social touch correlates inversely with autism traits', Neuropsychopharmacology, vol. 39, no. 9, pp. 2078-2085. https://doi.org/10.1038/npp.2014.78
Scheele, Dirk ; Kendrick, Keith M. ; Khouri, Christoph ; Kretzer, Elisa ; Schlaepfer, Thomas E. ; Stoffel-Wagner, Birgit ; Güntürkün, Onur ; Maier, Wolfgang ; Hurlemann, René. / An oxytocin-induced facilitation of neural and emotional responses to social touch correlates inversely with autism traits. In: Neuropsychopharmacology. 2014 ; Vol. 39, No. 9. pp. 2078-2085.
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