An overview of the diagnosis and management of nutrition in chronic pancreatitis

Elham Afghani, Amitasha Sinha, Vikesh Singh

Research output: Contribution to journalArticle

Abstract

Chronic pancreatitis is characterized by long-standing inflammation of the pancreas, which results in fibrosis and the gradual loss of pancreatic function. The loss of islets and acinar cells results in diabetes and exocrine insufficiency, respectively. Exocrine insufficiency can result in maldigestion of fat, protein, and carbohydrate as well as vitamins and minerals. Patients may present with variable severity of disease, from mild to severe. The diagnosis of chronic pancreatitis can be challenging, especially in patients with early or mild disease who have few to no morphologic abnormalities on standard abdominal imaging studies. A number of imaging modalities and tests have evolved to aid in the diagnosis of chronic pancreatitis based on changes in structure or function. Clinicians typically focus on treating pain in chronic pancreatitis as opposed to exocrine insufficiency, despite the fact that maldigestion and malabsorption can result in nutrition deficiencies. The aims of this review are to describe the various modalities used to diagnose chronic pancreatitis, to illustrate the nutrition deficiencies associated with exocrine insufficiency, and to provide an overview of nutrition assessment and treatment in these patients.

Original languageEnglish (US)
Pages (from-to)295-311
Number of pages17
JournalNutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
Volume29
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Chronic Pancreatitis
Nutrition Assessment
Acinar Cells
Islets of Langerhans
Vitamins
Minerals
Pancreas
Fibrosis
Fats
Carbohydrates
Inflammation
Pain
Proteins

Keywords

  • chronic pancreatitis
  • exocrine pancreatic insufficiency
  • malabsorption
  • maldigestion
  • pancreatic enzymes
  • vitamin deficiency

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Medicine(all)

Cite this

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