An overview of spaceflight-associated neuro-ocular syndrome (SANS)

Thomas Mader, C. Gibson, Neil R Miller, Prem Subramanian, Nimesh Patel, Andrew Lee

Research output: Contribution to journalReview article

Abstract

Over the last decade, the National Aeronautics and Space Administration's (NASA) Space Medicine Division has documented a variety of unusual physiological and pathological neuro-ophthalmic findings in astronauts during and following long duration space flight. These ndings include optic disc swelling, globe flattening, choroidal folds, and hyperopic shifts in refraction. Cephalad fluid shift has been proposed as a possible unifying etiology, but the specific mechanism responsible for these changes remains obscure. This manuscript reviews the history, clinical findings, and potential neurophysiologica l etiologies for spaceflight-associated neuro-ocular syndrome.

Original languageEnglish (US)
Pages (from-to)S206-S211
JournalNeurology India
Volume67
Issue number8
DOIs
StatePublished - May 1 2019

Fingerprint

Space Flight
Fluid Shifts
Aerospace Medicine
United States National Aeronautics and Space Administration
Astronauts
Optic Disk
History

Keywords

  • Choroidal folds
  • globe flattening
  • hyperopic shift
  • long-duration spaceflight
  • microgravity
  • optic disc swelling
  • spaceflight-associated neuro-ocular syndrome Key Message: Physiological and pathological neuro-ophthalmic findings occurring in astronauts during and following long-duration space flight are reviewed.

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Mader, T., Gibson, C., Miller, N. R., Subramanian, P., Patel, N., & Lee, A. (2019). An overview of spaceflight-associated neuro-ocular syndrome (SANS). Neurology India, 67(8), S206-S211. https://doi.org/10.4103/0028-3886.259126

An overview of spaceflight-associated neuro-ocular syndrome (SANS). / Mader, Thomas; Gibson, C.; Miller, Neil R; Subramanian, Prem; Patel, Nimesh; Lee, Andrew.

In: Neurology India, Vol. 67, No. 8, 01.05.2019, p. S206-S211.

Research output: Contribution to journalReview article

Mader, T, Gibson, C, Miller, NR, Subramanian, P, Patel, N & Lee, A 2019, 'An overview of spaceflight-associated neuro-ocular syndrome (SANS)', Neurology India, vol. 67, no. 8, pp. S206-S211. https://doi.org/10.4103/0028-3886.259126
Mader, Thomas ; Gibson, C. ; Miller, Neil R ; Subramanian, Prem ; Patel, Nimesh ; Lee, Andrew. / An overview of spaceflight-associated neuro-ocular syndrome (SANS). In: Neurology India. 2019 ; Vol. 67, No. 8. pp. S206-S211.
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