An overview of lung cancer genomics and proteomics

Courtney A. Granville, Phillip A. Dennis

Research output: Contribution to journalArticle

Abstract

Lung cancer is the cause of nearly 170,000 cancer deaths in the United States each year, accounting for nearly 25% of all deaths from cancer. The 5-yr survival rate for lung cancer is <15% from the time of diagnosis. This is largely due to the late stage of diagnosis and the lack of effective treatments, reflecting the need for a better understanding of the mechanisms that underlie lung carcinogenesis. Unlike the study of a single gene, protein, or pathway, genomic and proteomic technologies enable a systematic overview that provides the potential to improve our understanding of this disease. Ultimately, this could improve the diagnosis, prognosis, and clinical management of patients with lung cancer. Here, we review studies that generated profiles of gene and protein expression in lung cancer specimens and relevant model systems, and make recommendations to facilitate the clinical application of these technologies.

Original languageEnglish (US)
Pages (from-to)169-176
Number of pages8
JournalAmerican Journal of Respiratory Cell and Molecular Biology
Volume32
Issue number3
DOIs
StatePublished - Mar 2005
Externally publishedYes

Fingerprint

Genomics
Proteomics
Lung Neoplasms
Technology
Delayed Diagnosis
Proteins
Transcriptome
Neoplasms
Carcinogenesis
Survival Rate
Lung
Therapeutics

Keywords

  • Genomics
  • Lung cancer
  • Proteomics

ASJC Scopus subject areas

  • Cell Biology
  • Pulmonary and Respiratory Medicine
  • Molecular Biology

Cite this

An overview of lung cancer genomics and proteomics. / Granville, Courtney A.; Dennis, Phillip A.

In: American Journal of Respiratory Cell and Molecular Biology, Vol. 32, No. 3, 03.2005, p. 169-176.

Research output: Contribution to journalArticle

Granville, Courtney A. ; Dennis, Phillip A. / An overview of lung cancer genomics and proteomics. In: American Journal of Respiratory Cell and Molecular Biology. 2005 ; Vol. 32, No. 3. pp. 169-176.
@article{a0238157d57d4795837713fb9cb73b8f,
title = "An overview of lung cancer genomics and proteomics",
abstract = "Lung cancer is the cause of nearly 170,000 cancer deaths in the United States each year, accounting for nearly 25{\%} of all deaths from cancer. The 5-yr survival rate for lung cancer is <15{\%} from the time of diagnosis. This is largely due to the late stage of diagnosis and the lack of effective treatments, reflecting the need for a better understanding of the mechanisms that underlie lung carcinogenesis. Unlike the study of a single gene, protein, or pathway, genomic and proteomic technologies enable a systematic overview that provides the potential to improve our understanding of this disease. Ultimately, this could improve the diagnosis, prognosis, and clinical management of patients with lung cancer. Here, we review studies that generated profiles of gene and protein expression in lung cancer specimens and relevant model systems, and make recommendations to facilitate the clinical application of these technologies.",
keywords = "Genomics, Lung cancer, Proteomics",
author = "Granville, {Courtney A.} and Dennis, {Phillip A.}",
year = "2005",
month = "3",
doi = "10.1165/rcmb.F290",
language = "English (US)",
volume = "32",
pages = "169--176",
journal = "American Journal of Respiratory Cell and Molecular Biology",
issn = "1044-1549",
publisher = "American Thoracic Society",
number = "3",

}

TY - JOUR

T1 - An overview of lung cancer genomics and proteomics

AU - Granville, Courtney A.

AU - Dennis, Phillip A.

PY - 2005/3

Y1 - 2005/3

N2 - Lung cancer is the cause of nearly 170,000 cancer deaths in the United States each year, accounting for nearly 25% of all deaths from cancer. The 5-yr survival rate for lung cancer is <15% from the time of diagnosis. This is largely due to the late stage of diagnosis and the lack of effective treatments, reflecting the need for a better understanding of the mechanisms that underlie lung carcinogenesis. Unlike the study of a single gene, protein, or pathway, genomic and proteomic technologies enable a systematic overview that provides the potential to improve our understanding of this disease. Ultimately, this could improve the diagnosis, prognosis, and clinical management of patients with lung cancer. Here, we review studies that generated profiles of gene and protein expression in lung cancer specimens and relevant model systems, and make recommendations to facilitate the clinical application of these technologies.

AB - Lung cancer is the cause of nearly 170,000 cancer deaths in the United States each year, accounting for nearly 25% of all deaths from cancer. The 5-yr survival rate for lung cancer is <15% from the time of diagnosis. This is largely due to the late stage of diagnosis and the lack of effective treatments, reflecting the need for a better understanding of the mechanisms that underlie lung carcinogenesis. Unlike the study of a single gene, protein, or pathway, genomic and proteomic technologies enable a systematic overview that provides the potential to improve our understanding of this disease. Ultimately, this could improve the diagnosis, prognosis, and clinical management of patients with lung cancer. Here, we review studies that generated profiles of gene and protein expression in lung cancer specimens and relevant model systems, and make recommendations to facilitate the clinical application of these technologies.

KW - Genomics

KW - Lung cancer

KW - Proteomics

UR - http://www.scopus.com/inward/record.url?scp=15044341779&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=15044341779&partnerID=8YFLogxK

U2 - 10.1165/rcmb.F290

DO - 10.1165/rcmb.F290

M3 - Article

C2 - 15713815

AN - SCOPUS:15044341779

VL - 32

SP - 169

EP - 176

JO - American Journal of Respiratory Cell and Molecular Biology

JF - American Journal of Respiratory Cell and Molecular Biology

SN - 1044-1549

IS - 3

ER -