An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium

Ting Yat Wong, Joaquim Radua, Edith Pomarol-Clotet, Raymond Salvador, Anton Albajes-Eizagirre, Aleix Solanes, Erick J. Canales-Rodriguez, Amalia Guerrero-Pedraza, Salvador Sarro, Tilo Kircher, Igor Nenadic, Axel Krug, Dominik Grotegerd, Udo Dannlowski, Stefan Borgwardt, Anita Riecher-Rössler, Andre Schmidt, Christina Andreou, Christian G. Huber, Jessica TurnerVince Calhoun, Wenhao Jiang, Sarah Clark, Esther Walton, Gianfranco Spalletta, Nerisa Banaj, Fabrizio Piras, Valentina Ciullo, Daniela Vecchio, Irina Lebedeva, Alexander S. Tomyshev, Vasily Kaleda, Tatyana Klushnik, Geraldo Busatto Filho, Marcus Vinicius Zanetti, Mauricio Henriques Serpa, Pedro Gomes Penteado Rosa, Ryota Hashimoto, Masaki Fukunaga, Anja Richter, Bernd Krämer, Oliver Gruber, Aristotle N. Voineskos, Erin W. Dickie, David Tomecek, Antonin Skoch, Filip Spaniel, Cyril Hoschl, Alessandro Bertolino, Aurora Bonvino, Annabella Di Giorgio, Laurena Holleran, Simone Ciufolini, Tiago Reis Marques, Paola Dazzan, Robin Murray, Jelle Lamsma, Wiepke Cahn, Neeltje Van Haren, Ana M. Díaz-Zuluaga, Julián A. Pineda-Zapata, Cristian Vargas, Carlos López-Jaramillo, Theo G.M. Van Erp, Ruben C. Gur, Thomas Nickl-Jockschat

Research output: Contribution to journalArticle

Abstract

BackgroundPositive symptoms are a useful predictor of aggression in schizophrenia. Although a similar pattern of abnormal brain structures related to both positive symptoms and aggression has been reported, this observation has not yet been confirmed in a single sample.MethodTo study the association between positive symptoms and aggression in schizophrenia on a neurobiological level, a prospective meta-analytic approach was employed to analyze harmonized structural neuroimaging data from 10 research centers worldwide. We analyzed brain MRI scans from 902 individuals with a primary diagnosis of schizophrenia and 952 healthy controls.ResultsThe result identified a widespread cortical thickness reduction in schizophrenia compared to their controls. Two separate meta-regression analyses revealed that a common pattern of reduced cortical gray matter thickness within the left lateral temporal lobe and right midcingulate cortex was significantly associated with both positive symptoms and aggression.ConclusionThese findings suggested that positive symptoms such as formal thought disorder and auditory misperception, combined with cognitive impairments reflecting difficulties in deploying an adaptive control toward perceived threats, could escalate the likelihood of aggression in schizophrenia.

Original languageEnglish (US)
JournalPsychological medicine
DOIs
StateAccepted/In press - Jan 1 2019
Externally publishedYes

Fingerprint

Aggression
Schizophrenia
Brain
Temporal Lobe
Neuroimaging
Meta-Analysis
Regression Analysis
Magnetic Resonance Imaging
Research

Keywords

  • Aggression
  • cerebral cortical thinning
  • hostility
  • impulse control
  • positive symptoms
  • prospective meta-analysis
  • schizophrenia

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

Cite this

An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium. / Wong, Ting Yat; Radua, Joaquim; Pomarol-Clotet, Edith; Salvador, Raymond; Albajes-Eizagirre, Anton; Solanes, Aleix; Canales-Rodriguez, Erick J.; Guerrero-Pedraza, Amalia; Sarro, Salvador; Kircher, Tilo; Nenadic, Igor; Krug, Axel; Grotegerd, Dominik; Dannlowski, Udo; Borgwardt, Stefan; Riecher-Rössler, Anita; Schmidt, Andre; Andreou, Christina; Huber, Christian G.; Turner, Jessica; Calhoun, Vince; Jiang, Wenhao; Clark, Sarah; Walton, Esther; Spalletta, Gianfranco; Banaj, Nerisa; Piras, Fabrizio; Ciullo, Valentina; Vecchio, Daniela; Lebedeva, Irina; Tomyshev, Alexander S.; Kaleda, Vasily; Klushnik, Tatyana; Filho, Geraldo Busatto; Zanetti, Marcus Vinicius; Serpa, Mauricio Henriques; Penteado Rosa, Pedro Gomes; Hashimoto, Ryota; Fukunaga, Masaki; Richter, Anja; Krämer, Bernd; Gruber, Oliver; Voineskos, Aristotle N.; Dickie, Erin W.; Tomecek, David; Skoch, Antonin; Spaniel, Filip; Hoschl, Cyril; Bertolino, Alessandro; Bonvino, Aurora; Di Giorgio, Annabella; Holleran, Laurena; Ciufolini, Simone; Marques, Tiago Reis; Dazzan, Paola; Murray, Robin; Lamsma, Jelle; Cahn, Wiepke; Van Haren, Neeltje; Díaz-Zuluaga, Ana M.; Pineda-Zapata, Julián A.; Vargas, Cristian; López-Jaramillo, Carlos; Van Erp, Theo G.M.; Gur, Ruben C.; Nickl-Jockschat, Thomas.

In: Psychological medicine, 01.01.2019.

Research output: Contribution to journalArticle

Wong, TY, Radua, J, Pomarol-Clotet, E, Salvador, R, Albajes-Eizagirre, A, Solanes, A, Canales-Rodriguez, EJ, Guerrero-Pedraza, A, Sarro, S, Kircher, T, Nenadic, I, Krug, A, Grotegerd, D, Dannlowski, U, Borgwardt, S, Riecher-Rössler, A, Schmidt, A, Andreou, C, Huber, CG, Turner, J, Calhoun, V, Jiang, W, Clark, S, Walton, E, Spalletta, G, Banaj, N, Piras, F, Ciullo, V, Vecchio, D, Lebedeva, I, Tomyshev, AS, Kaleda, V, Klushnik, T, Filho, GB, Zanetti, MV, Serpa, MH, Penteado Rosa, PG, Hashimoto, R, Fukunaga, M, Richter, A, Krämer, B, Gruber, O, Voineskos, AN, Dickie, EW, Tomecek, D, Skoch, A, Spaniel, F, Hoschl, C, Bertolino, A, Bonvino, A, Di Giorgio, A, Holleran, L, Ciufolini, S, Marques, TR, Dazzan, P, Murray, R, Lamsma, J, Cahn, W, Van Haren, N, Díaz-Zuluaga, AM, Pineda-Zapata, JA, Vargas, C, López-Jaramillo, C, Van Erp, TGM, Gur, RC & Nickl-Jockschat, T 2019, 'An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium', Psychological medicine. https://doi.org/10.1017/S0033291719002149
Wong, Ting Yat ; Radua, Joaquim ; Pomarol-Clotet, Edith ; Salvador, Raymond ; Albajes-Eizagirre, Anton ; Solanes, Aleix ; Canales-Rodriguez, Erick J. ; Guerrero-Pedraza, Amalia ; Sarro, Salvador ; Kircher, Tilo ; Nenadic, Igor ; Krug, Axel ; Grotegerd, Dominik ; Dannlowski, Udo ; Borgwardt, Stefan ; Riecher-Rössler, Anita ; Schmidt, Andre ; Andreou, Christina ; Huber, Christian G. ; Turner, Jessica ; Calhoun, Vince ; Jiang, Wenhao ; Clark, Sarah ; Walton, Esther ; Spalletta, Gianfranco ; Banaj, Nerisa ; Piras, Fabrizio ; Ciullo, Valentina ; Vecchio, Daniela ; Lebedeva, Irina ; Tomyshev, Alexander S. ; Kaleda, Vasily ; Klushnik, Tatyana ; Filho, Geraldo Busatto ; Zanetti, Marcus Vinicius ; Serpa, Mauricio Henriques ; Penteado Rosa, Pedro Gomes ; Hashimoto, Ryota ; Fukunaga, Masaki ; Richter, Anja ; Krämer, Bernd ; Gruber, Oliver ; Voineskos, Aristotle N. ; Dickie, Erin W. ; Tomecek, David ; Skoch, Antonin ; Spaniel, Filip ; Hoschl, Cyril ; Bertolino, Alessandro ; Bonvino, Aurora ; Di Giorgio, Annabella ; Holleran, Laurena ; Ciufolini, Simone ; Marques, Tiago Reis ; Dazzan, Paola ; Murray, Robin ; Lamsma, Jelle ; Cahn, Wiepke ; Van Haren, Neeltje ; Díaz-Zuluaga, Ana M. ; Pineda-Zapata, Julián A. ; Vargas, Cristian ; López-Jaramillo, Carlos ; Van Erp, Theo G.M. ; Gur, Ruben C. ; Nickl-Jockschat, Thomas. / An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium. In: Psychological medicine. 2019.
@article{c459cc03284a41eeb42340e4a925c6d6,
title = "An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium",
abstract = "BackgroundPositive symptoms are a useful predictor of aggression in schizophrenia. Although a similar pattern of abnormal brain structures related to both positive symptoms and aggression has been reported, this observation has not yet been confirmed in a single sample.MethodTo study the association between positive symptoms and aggression in schizophrenia on a neurobiological level, a prospective meta-analytic approach was employed to analyze harmonized structural neuroimaging data from 10 research centers worldwide. We analyzed brain MRI scans from 902 individuals with a primary diagnosis of schizophrenia and 952 healthy controls.ResultsThe result identified a widespread cortical thickness reduction in schizophrenia compared to their controls. Two separate meta-regression analyses revealed that a common pattern of reduced cortical gray matter thickness within the left lateral temporal lobe and right midcingulate cortex was significantly associated with both positive symptoms and aggression.ConclusionThese findings suggested that positive symptoms such as formal thought disorder and auditory misperception, combined with cognitive impairments reflecting difficulties in deploying an adaptive control toward perceived threats, could escalate the likelihood of aggression in schizophrenia.",
keywords = "Aggression, cerebral cortical thinning, hostility, impulse control, positive symptoms, prospective meta-analysis, schizophrenia",
author = "Wong, {Ting Yat} and Joaquim Radua and Edith Pomarol-Clotet and Raymond Salvador and Anton Albajes-Eizagirre and Aleix Solanes and Canales-Rodriguez, {Erick J.} and Amalia Guerrero-Pedraza and Salvador Sarro and Tilo Kircher and Igor Nenadic and Axel Krug and Dominik Grotegerd and Udo Dannlowski and Stefan Borgwardt and Anita Riecher-R{\"o}ssler and Andre Schmidt and Christina Andreou and Huber, {Christian G.} and Jessica Turner and Vince Calhoun and Wenhao Jiang and Sarah Clark and Esther Walton and Gianfranco Spalletta and Nerisa Banaj and Fabrizio Piras and Valentina Ciullo and Daniela Vecchio and Irina Lebedeva and Tomyshev, {Alexander S.} and Vasily Kaleda and Tatyana Klushnik and Filho, {Geraldo Busatto} and Zanetti, {Marcus Vinicius} and Serpa, {Mauricio Henriques} and {Penteado Rosa}, {Pedro Gomes} and Ryota Hashimoto and Masaki Fukunaga and Anja Richter and Bernd Kr{\"a}mer and Oliver Gruber and Voineskos, {Aristotle N.} and Dickie, {Erin W.} and David Tomecek and Antonin Skoch and Filip Spaniel and Cyril Hoschl and Alessandro Bertolino and Aurora Bonvino and {Di Giorgio}, Annabella and Laurena Holleran and Simone Ciufolini and Marques, {Tiago Reis} and Paola Dazzan and Robin Murray and Jelle Lamsma and Wiepke Cahn and {Van Haren}, Neeltje and D{\'i}az-Zuluaga, {Ana M.} and Pineda-Zapata, {Juli{\'a}n A.} and Cristian Vargas and Carlos L{\'o}pez-Jaramillo and {Van Erp}, {Theo G.M.} and Gur, {Ruben C.} and Thomas Nickl-Jockschat",
year = "2019",
month = "1",
day = "1",
doi = "10.1017/S0033291719002149",
language = "English (US)",
journal = "Psychological Medicine",
issn = "0033-2917",
publisher = "Cambridge University Press",

}

TY - JOUR

T1 - An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium

AU - Wong, Ting Yat

AU - Radua, Joaquim

AU - Pomarol-Clotet, Edith

AU - Salvador, Raymond

AU - Albajes-Eizagirre, Anton

AU - Solanes, Aleix

AU - Canales-Rodriguez, Erick J.

AU - Guerrero-Pedraza, Amalia

AU - Sarro, Salvador

AU - Kircher, Tilo

AU - Nenadic, Igor

AU - Krug, Axel

AU - Grotegerd, Dominik

AU - Dannlowski, Udo

AU - Borgwardt, Stefan

AU - Riecher-Rössler, Anita

AU - Schmidt, Andre

AU - Andreou, Christina

AU - Huber, Christian G.

AU - Turner, Jessica

AU - Calhoun, Vince

AU - Jiang, Wenhao

AU - Clark, Sarah

AU - Walton, Esther

AU - Spalletta, Gianfranco

AU - Banaj, Nerisa

AU - Piras, Fabrizio

AU - Ciullo, Valentina

AU - Vecchio, Daniela

AU - Lebedeva, Irina

AU - Tomyshev, Alexander S.

AU - Kaleda, Vasily

AU - Klushnik, Tatyana

AU - Filho, Geraldo Busatto

AU - Zanetti, Marcus Vinicius

AU - Serpa, Mauricio Henriques

AU - Penteado Rosa, Pedro Gomes

AU - Hashimoto, Ryota

AU - Fukunaga, Masaki

AU - Richter, Anja

AU - Krämer, Bernd

AU - Gruber, Oliver

AU - Voineskos, Aristotle N.

AU - Dickie, Erin W.

AU - Tomecek, David

AU - Skoch, Antonin

AU - Spaniel, Filip

AU - Hoschl, Cyril

AU - Bertolino, Alessandro

AU - Bonvino, Aurora

AU - Di Giorgio, Annabella

AU - Holleran, Laurena

AU - Ciufolini, Simone

AU - Marques, Tiago Reis

AU - Dazzan, Paola

AU - Murray, Robin

AU - Lamsma, Jelle

AU - Cahn, Wiepke

AU - Van Haren, Neeltje

AU - Díaz-Zuluaga, Ana M.

AU - Pineda-Zapata, Julián A.

AU - Vargas, Cristian

AU - López-Jaramillo, Carlos

AU - Van Erp, Theo G.M.

AU - Gur, Ruben C.

AU - Nickl-Jockschat, Thomas

PY - 2019/1/1

Y1 - 2019/1/1

N2 - BackgroundPositive symptoms are a useful predictor of aggression in schizophrenia. Although a similar pattern of abnormal brain structures related to both positive symptoms and aggression has been reported, this observation has not yet been confirmed in a single sample.MethodTo study the association between positive symptoms and aggression in schizophrenia on a neurobiological level, a prospective meta-analytic approach was employed to analyze harmonized structural neuroimaging data from 10 research centers worldwide. We analyzed brain MRI scans from 902 individuals with a primary diagnosis of schizophrenia and 952 healthy controls.ResultsThe result identified a widespread cortical thickness reduction in schizophrenia compared to their controls. Two separate meta-regression analyses revealed that a common pattern of reduced cortical gray matter thickness within the left lateral temporal lobe and right midcingulate cortex was significantly associated with both positive symptoms and aggression.ConclusionThese findings suggested that positive symptoms such as formal thought disorder and auditory misperception, combined with cognitive impairments reflecting difficulties in deploying an adaptive control toward perceived threats, could escalate the likelihood of aggression in schizophrenia.

AB - BackgroundPositive symptoms are a useful predictor of aggression in schizophrenia. Although a similar pattern of abnormal brain structures related to both positive symptoms and aggression has been reported, this observation has not yet been confirmed in a single sample.MethodTo study the association between positive symptoms and aggression in schizophrenia on a neurobiological level, a prospective meta-analytic approach was employed to analyze harmonized structural neuroimaging data from 10 research centers worldwide. We analyzed brain MRI scans from 902 individuals with a primary diagnosis of schizophrenia and 952 healthy controls.ResultsThe result identified a widespread cortical thickness reduction in schizophrenia compared to their controls. Two separate meta-regression analyses revealed that a common pattern of reduced cortical gray matter thickness within the left lateral temporal lobe and right midcingulate cortex was significantly associated with both positive symptoms and aggression.ConclusionThese findings suggested that positive symptoms such as formal thought disorder and auditory misperception, combined with cognitive impairments reflecting difficulties in deploying an adaptive control toward perceived threats, could escalate the likelihood of aggression in schizophrenia.

KW - Aggression

KW - cerebral cortical thinning

KW - hostility

KW - impulse control

KW - positive symptoms

KW - prospective meta-analysis

KW - schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=85073743434&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073743434&partnerID=8YFLogxK

U2 - 10.1017/S0033291719002149

DO - 10.1017/S0033291719002149

M3 - Article

C2 - 31615588

AN - SCOPUS:85073743434

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

ER -