Abstract
Osteopontin (SPP1) is a soluble ligand with pleomorphic immunologic activities including activation of macrophage chemotaxis, promotion of Th1 responses, and activation of B1 B cells. It has been implicated in the development of murine lupus and is overexpressed in humans with systemic lupus erythematosus (SLE). We examined a polymorphism of osteopontin for an association with lupus in humans in an effort to determine whether there is any evidence that a genetic predisposition to altered osteopontin expression might explain the overexpression seen in human SLE patients. A silent polymorphism (707C>T, rs1126616) of osteopontin was significantly associated with SLE. Additional associations with renal disease and opportunisitic infections were suggested. This is the first phenotypic association with a polymorphic variant of osteopontin.
Original language | English (US) |
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Pages (from-to) | 459 |
Number of pages | 1 |
Journal | Human mutation |
Volume | 19 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2002 |
ASJC Scopus subject areas
- Genetics
- Genetics(clinical)