An optimized radiosynthesis of [18F]FNDP, a positron emission tomography radiotracer for imaging soluble epoxide hydrolase (sEH)

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Abstract

In this concise practitioner protocol, the radiochemical synthesis of [18F]FNDP suitable for human positron emission tomography studies is described and the results from validation productions are presented. The high specific activity radiotracer product is prepared as a sterile, apyrogenic solution that conforms to current Good Manufacturing Practice requirements.

Original languageEnglish (US)
JournalJournal of Labelled Compounds and Radiopharmaceuticals
DOIs
StateAccepted/In press - Jan 1 2018

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Keywords

  • Brain Disorders
  • Hypertension
  • Pracitioner Protocol
  • Soluble Epoxide Hydrolase

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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