An optimized radiosynthesis of [18F]FNDP, a positron emission tomography radiotracer for imaging soluble epoxide hydrolase (sEH)

Research output: Contribution to journalArticle

Abstract

In this concise practitioner protocol, the radiochemical synthesis of [18F]FNDP suitable for human positron emission tomography studies is described and the results from validation productions are presented. The high specific activity radiotracer product is prepared as a sterile, apyrogenic solution that conforms to current Good Manufacturing Practice requirements.

Original languageEnglish (US)
JournalJournal of Labelled Compounds and Radiopharmaceuticals
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Epoxide Hydrolases
Positron emission tomography
Positron-Emission Tomography
Imaging techniques

Keywords

  • Brain Disorders
  • Hypertension
  • Pracitioner Protocol
  • Soluble Epoxide Hydrolase

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

Cite this

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abstract = "In this concise practitioner protocol, the radiochemical synthesis of [18F]FNDP suitable for human positron emission tomography studies is described and the results from validation productions are presented. The high specific activity radiotracer product is prepared as a sterile, apyrogenic solution that conforms to current Good Manufacturing Practice requirements.",
keywords = "Brain Disorders, Hypertension, Pracitioner Protocol, Soluble Epoxide Hydrolase",
author = "{Behnam Azad}, Babak and Daniel Holt and Ravert, {Hayden T.} and Andrew Horti and Dannals, {Robert F}",
year = "2018",
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language = "English (US)",
journal = "Journal of Labelled Compounds and Radiopharmaceuticals",
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AU - Holt, Daniel

AU - Ravert, Hayden T.

AU - Horti, Andrew

AU - Dannals, Robert F

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KW - Brain Disorders

KW - Hypertension

KW - Pracitioner Protocol

KW - Soluble Epoxide Hydrolase

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