An odorant-binding protein required for suppression of sweet taste by bitter chemicals

YongTaek Jeong, Jaewon Shim, SoRa Oh, HongIn Yoon, ChulHoon Kim, SeokJun Moon, Craig Montell

Research output: Contribution to journalArticle

Abstract

Animals often must decide whether or not to consume a diet that contains competing attractive and aversive compounds. Here, using the fruit fly, Drosophila melanogaster, we describe a mechanism that influences this decision. Addition of bitter compounds to sucrose suppressed feeding behavior, and this inhibition depended on an odorant-binding protein (OBP) termed OBP49a. In wild-type flies, bitter compounds suppressed sucrose-induced action potentials, and the inhibition was impaired in Obp49a mutants. However, loss of OBP49a did not affect action potentials in sugar- or bitter-activated gustatory receptor neurons (GRNs) when the GRNs were presented with just one type of tastant. OBP49a was expressed in accessory cells and acted non-cell-autonomously to attenuate nerve firings in sugar-activated GRNs when bitter compounds were combined with sucrose. These findings demonstrate an unexpected role for an OBP in taste andidentify a molecular player involved in the integration of opposing attractive and aversive gustatory inputs

Original languageEnglish (US)
Pages (from-to)725-737
Number of pages13
JournalNeuron
Volume79
Issue number4
DOIs
StatePublished - Aug 21 2013
Externally publishedYes

Fingerprint

Sucrose
Neurons
Diptera
Action Potentials
Feeding Behavior
Drosophila melanogaster
Fruit
odorant-binding protein
Diet
Inhibition (Psychology)

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Jeong, Y., Shim, J., Oh, S., Yoon, H., Kim, C., Moon, S., & Montell, C. (2013). An odorant-binding protein required for suppression of sweet taste by bitter chemicals. Neuron, 79(4), 725-737. https://doi.org/10.1016/j.neuron.2013.06.025

An odorant-binding protein required for suppression of sweet taste by bitter chemicals. / Jeong, YongTaek; Shim, Jaewon; Oh, SoRa; Yoon, HongIn; Kim, ChulHoon; Moon, SeokJun; Montell, Craig.

In: Neuron, Vol. 79, No. 4, 21.08.2013, p. 725-737.

Research output: Contribution to journalArticle

Jeong, Y, Shim, J, Oh, S, Yoon, H, Kim, C, Moon, S & Montell, C 2013, 'An odorant-binding protein required for suppression of sweet taste by bitter chemicals', Neuron, vol. 79, no. 4, pp. 725-737. https://doi.org/10.1016/j.neuron.2013.06.025
Jeong, YongTaek ; Shim, Jaewon ; Oh, SoRa ; Yoon, HongIn ; Kim, ChulHoon ; Moon, SeokJun ; Montell, Craig. / An odorant-binding protein required for suppression of sweet taste by bitter chemicals. In: Neuron. 2013 ; Vol. 79, No. 4. pp. 725-737.
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