An isotope release cytotoxicity assay applicable to human tumors: The use of 11 indium

P. Frost, R. Wiltrout, Z. Maciorowski, N. R. Rose

Research output: Contribution to journalArticle

Abstract

We have demonstrated that human tumors can be labelled efficiently with the indium-oxine chelate. Subsequently, this isotope can be released by cytotoxic lymphoid cells. Both natural and induced cytotoxicity can be demonstrated utilizing this isotope release method. Because of the slow spontaneous release of 1 indium and its efficient labelling of human tumor cells, this isotope release assay can be utilized in long-term cytotoxic assays in the study of human tumor immunology.

Original languageEnglish (US)
Pages (from-to)102-104
Number of pages3
JournalOncology
Volume34
Issue number3
DOIs
StatePublished - 1977
Externally publishedYes

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Indium
Isotopes
Neoplasms
Allergy and Immunology
Lymphocytes

Keywords

  • Cytotoxicity-Human tumors-111 Indium

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

An isotope release cytotoxicity assay applicable to human tumors : The use of 11 indium. / Frost, P.; Wiltrout, R.; Maciorowski, Z.; Rose, N. R.

In: Oncology, Vol. 34, No. 3, 1977, p. 102-104.

Research output: Contribution to journalArticle

Frost, P, Wiltrout, R, Maciorowski, Z & Rose, NR 1977, 'An isotope release cytotoxicity assay applicable to human tumors: The use of 11 indium', Oncology, vol. 34, no. 3, pp. 102-104. https://doi.org/10.1159/000225200
Frost, P. ; Wiltrout, R. ; Maciorowski, Z. ; Rose, N. R. / An isotope release cytotoxicity assay applicable to human tumors : The use of 11 indium. In: Oncology. 1977 ; Vol. 34, No. 3. pp. 102-104.
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