An investigation of candidate regions for association with bipolar disorder

NIMH Genetics Initiative Bipolar Disorder Consortium

Research output: Contribution to journalArticle

Abstract

We performed a case-control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8Mb region on chromosome 6 (105-113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P-values of 2×10-5). Both P-values are in the top 5% of the distribution derived from null simulations (P=0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP.

Original languageEnglish (US)
Pages (from-to)1292-1297
Number of pages6
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume153
Issue number7
DOIs
StatePublished - Oct 1 2010

Keywords

  • Association
  • Bipolar disorder
  • Genetics

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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