An inverse correlation between spontaneous eye-blink rate and platelet monoamine oxidase activity

C. N. Karson; J. E. Kleinman; K. F. Berman; B. H. Phelps; C. D. Wise; L. E. DeLisi; D. V. Jeste

doi:10.1192/bjp.142.1.43

An inverse correlation between spontaneous eye-blink rate and platelet monoamine oxidase activity

C. N. Karson, J. E. Kleinman, K. F. Berman, B. H. Phelps, C. D. Wise, L. E. DeLisi, D. V. Jeste

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Abstract

An inverse correlation between platelet monoamine oxidase activity and spontaneous eye-blink rate, a putative measure of central dopaminergic activity, was found in medication-free chronic schizophrenic patients without tardive dyskinesia (n = 20, r(s) = -.47, P<.025). A similar correlation was found when patients with tardive dyskinesia were included but was weaker (n = 27, r(s) = -.35, P<.05). Normal controls and patients with tardive dyskinesia did not demonstrate this relationship. This report confirms a previous finding of a significant platelet monoamine oxidase-blink rate correlation in chronic schizophrenic patients. Insofar as this relationship is mediated by dopamine, it suggests that dopaminergic relations are more readily demonstrated in schizophrenic subjects than normals. Moreover, tardive dyskinesia appears to obscure this dopaminergic relationship.

Original language	English (US)
Pages (from-to)	43-46
Number of pages	4
Journal	Unknown Journal
Volume	142
Issue number	1
DOIs	https://doi.org/10.1192/bjp.142.1.43
State	Published - Jan 1 1983
Externally published	Yes

ASJC Scopus subject areas

Psychiatry and Mental health

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title = "An inverse correlation between spontaneous eye-blink rate and platelet monoamine oxidase activity",

abstract = "An inverse correlation between platelet monoamine oxidase activity and spontaneous eye-blink rate, a putative measure of central dopaminergic activity, was found in medication-free chronic schizophrenic patients without tardive dyskinesia (n = 20, r(s) = -.47, P<.025). A similar correlation was found when patients with tardive dyskinesia were included but was weaker (n = 27, r(s) = -.35, P<.05). Normal controls and patients with tardive dyskinesia did not demonstrate this relationship. This report confirms a previous finding of a significant platelet monoamine oxidase-blink rate correlation in chronic schizophrenic patients. Insofar as this relationship is mediated by dopamine, it suggests that dopaminergic relations are more readily demonstrated in schizophrenic subjects than normals. Moreover, tardive dyskinesia appears to obscure this dopaminergic relationship.",

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AU - Karson, C. N.

AU - Kleinman, J. E.

AU - Berman, K. F.

AU - Phelps, B. H.

AU - Wise, C. D.

AU - DeLisi, L. E.

AU - Jeste, D. V.

PY - 1983/1/1

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N2 - An inverse correlation between platelet monoamine oxidase activity and spontaneous eye-blink rate, a putative measure of central dopaminergic activity, was found in medication-free chronic schizophrenic patients without tardive dyskinesia (n = 20, r(s) = -.47, P<.025). A similar correlation was found when patients with tardive dyskinesia were included but was weaker (n = 27, r(s) = -.35, P<.05). Normal controls and patients with tardive dyskinesia did not demonstrate this relationship. This report confirms a previous finding of a significant platelet monoamine oxidase-blink rate correlation in chronic schizophrenic patients. Insofar as this relationship is mediated by dopamine, it suggests that dopaminergic relations are more readily demonstrated in schizophrenic subjects than normals. Moreover, tardive dyskinesia appears to obscure this dopaminergic relationship.

AB - An inverse correlation between platelet monoamine oxidase activity and spontaneous eye-blink rate, a putative measure of central dopaminergic activity, was found in medication-free chronic schizophrenic patients without tardive dyskinesia (n = 20, r(s) = -.47, P<.025). A similar correlation was found when patients with tardive dyskinesia were included but was weaker (n = 27, r(s) = -.35, P<.05). Normal controls and patients with tardive dyskinesia did not demonstrate this relationship. This report confirms a previous finding of a significant platelet monoamine oxidase-blink rate correlation in chronic schizophrenic patients. Insofar as this relationship is mediated by dopamine, it suggests that dopaminergic relations are more readily demonstrated in schizophrenic subjects than normals. Moreover, tardive dyskinesia appears to obscure this dopaminergic relationship.

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An inverse correlation between spontaneous eye-blink rate and platelet monoamine oxidase activity

Abstract

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