An interventional study of rice for reducing cadmium exposure in a Chinese industrial town

Lei Huang, Linli Liu, Ting Zhang, Di Zhao, Hongbo Li, Hong Sun, Patrick L. Kinney, Masha Pitiranggon, Steven Chillrud, Lena Qiying Ma, Ana Navas Acien, Jun Bi, Beizhan Yan

Research output: Contribution to journalArticle

Abstract

Background: Reducing cadmium (Cd) exposure in Cd-polluted areas in Asia is urgently needed given the toxic effects of Cd. The short-term and long-term benefits of lowering Cd exposure are unknown because of its long half-life in the body. Objectives: We aimed to investigate whether an intervention with low-Cd rice in a contaminated area of China reduced urinary Cd (UCd) levels and improved blood pressure and kidney function outcomes compared to no-intervention in consumers of high-Cd rice in the same region. Methods: 106 non-smoking subjects were divided into three treatment groups: the intervention group (replacing homegrown high-Cd rice with market low-Cd rice, n = 34), the non-intervention group (continue eating high-Cd rice, n = 36) and the control group (continued eating low-Cd rice they have been eating for years, n = 36). The intervention period lasted for almost 8 months, during which participants were visited on up to 4 occasions and UCd, systolic and diastolic blood pressure (SBP, DBP), kidney function biomarkers (β2-microglobulin and N-acetyl-β-D-glucosaminidase) were measured. Results: After 3 months, the geometric mean UCd in the intervention (Int) group decreased significantly by 0.32 μg/g (p = 0.007), while changes were not significant in the non-intervention (non-Int) group (0.13 μg/g, p = 0.95) or the control group (−0.01 μg/g, p = 0.52). UCd in the Int group remained lower than in the non-Int group but higher than in the Control group through the end of follow up. DBP in the Int group decreased significantly from 80 mm Hg at month three (p = 0.03) and stayed around 74 mm Hg for the remainder of the study. SBP also decreased in the Int group but with variations similar to those observed in the other two groups. The two kidney biomarkers showed variations without a clear pattern. Conclusion: This study suggested that UCd reflected both short-term (<3 months) and long-term Cd exposure. In addition, the low-Cd rice intervention showed initial benefits in lowering blood pressure levels, especially DBP, but not kidney biomarkers.

Original languageEnglish (US)
JournalEnvironment International
DOIs
StateAccepted/In press - Jan 1 2018
Externally publishedYes

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cadmium
rice
biomarker
blood
exposure
half life
market

Keywords

  • Blood pressure
  • Cadmium exposure
  • Intervention
  • Kidney dysfunction
  • Rice
  • Urinary cadmium

ASJC Scopus subject areas

  • Environmental Science(all)

Cite this

An interventional study of rice for reducing cadmium exposure in a Chinese industrial town. / Huang, Lei; Liu, Linli; Zhang, Ting; Zhao, Di; Li, Hongbo; Sun, Hong; Kinney, Patrick L.; Pitiranggon, Masha; Chillrud, Steven; Ma, Lena Qiying; Navas Acien, Ana; Bi, Jun; Yan, Beizhan.

In: Environment International, 01.01.2018.

Research output: Contribution to journalArticle

Huang, L, Liu, L, Zhang, T, Zhao, D, Li, H, Sun, H, Kinney, PL, Pitiranggon, M, Chillrud, S, Ma, LQ, Navas Acien, A, Bi, J & Yan, B 2018, 'An interventional study of rice for reducing cadmium exposure in a Chinese industrial town', Environment International. https://doi.org/10.1016/j.envint.2018.11.019
Huang, Lei ; Liu, Linli ; Zhang, Ting ; Zhao, Di ; Li, Hongbo ; Sun, Hong ; Kinney, Patrick L. ; Pitiranggon, Masha ; Chillrud, Steven ; Ma, Lena Qiying ; Navas Acien, Ana ; Bi, Jun ; Yan, Beizhan. / An interventional study of rice for reducing cadmium exposure in a Chinese industrial town. In: Environment International. 2018.
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abstract = "Background: Reducing cadmium (Cd) exposure in Cd-polluted areas in Asia is urgently needed given the toxic effects of Cd. The short-term and long-term benefits of lowering Cd exposure are unknown because of its long half-life in the body. Objectives: We aimed to investigate whether an intervention with low-Cd rice in a contaminated area of China reduced urinary Cd (UCd) levels and improved blood pressure and kidney function outcomes compared to no-intervention in consumers of high-Cd rice in the same region. Methods: 106 non-smoking subjects were divided into three treatment groups: the intervention group (replacing homegrown high-Cd rice with market low-Cd rice, n = 34), the non-intervention group (continue eating high-Cd rice, n = 36) and the control group (continued eating low-Cd rice they have been eating for years, n = 36). The intervention period lasted for almost 8 months, during which participants were visited on up to 4 occasions and UCd, systolic and diastolic blood pressure (SBP, DBP), kidney function biomarkers (β2-microglobulin and N-acetyl-β-D-glucosaminidase) were measured. Results: After 3 months, the geometric mean UCd in the intervention (Int) group decreased significantly by 0.32 μg/g (p = 0.007), while changes were not significant in the non-intervention (non-Int) group (0.13 μg/g, p = 0.95) or the control group (−0.01 μg/g, p = 0.52). UCd in the Int group remained lower than in the non-Int group but higher than in the Control group through the end of follow up. DBP in the Int group decreased significantly from 80 mm Hg at month three (p = 0.03) and stayed around 74 mm Hg for the remainder of the study. SBP also decreased in the Int group but with variations similar to those observed in the other two groups. The two kidney biomarkers showed variations without a clear pattern. Conclusion: This study suggested that UCd reflected both short-term (<3 months) and long-term Cd exposure. In addition, the low-Cd rice intervention showed initial benefits in lowering blood pressure levels, especially DBP, but not kidney biomarkers.",
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author = "Lei Huang and Linli Liu and Ting Zhang and Di Zhao and Hongbo Li and Hong Sun and Kinney, {Patrick L.} and Masha Pitiranggon and Steven Chillrud and Ma, {Lena Qiying} and {Navas Acien}, Ana and Jun Bi and Beizhan Yan",
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T1 - An interventional study of rice for reducing cadmium exposure in a Chinese industrial town

AU - Huang, Lei

AU - Liu, Linli

AU - Zhang, Ting

AU - Zhao, Di

AU - Li, Hongbo

AU - Sun, Hong

AU - Kinney, Patrick L.

AU - Pitiranggon, Masha

AU - Chillrud, Steven

AU - Ma, Lena Qiying

AU - Navas Acien, Ana

AU - Bi, Jun

AU - Yan, Beizhan

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Reducing cadmium (Cd) exposure in Cd-polluted areas in Asia is urgently needed given the toxic effects of Cd. The short-term and long-term benefits of lowering Cd exposure are unknown because of its long half-life in the body. Objectives: We aimed to investigate whether an intervention with low-Cd rice in a contaminated area of China reduced urinary Cd (UCd) levels and improved blood pressure and kidney function outcomes compared to no-intervention in consumers of high-Cd rice in the same region. Methods: 106 non-smoking subjects were divided into three treatment groups: the intervention group (replacing homegrown high-Cd rice with market low-Cd rice, n = 34), the non-intervention group (continue eating high-Cd rice, n = 36) and the control group (continued eating low-Cd rice they have been eating for years, n = 36). The intervention period lasted for almost 8 months, during which participants were visited on up to 4 occasions and UCd, systolic and diastolic blood pressure (SBP, DBP), kidney function biomarkers (β2-microglobulin and N-acetyl-β-D-glucosaminidase) were measured. Results: After 3 months, the geometric mean UCd in the intervention (Int) group decreased significantly by 0.32 μg/g (p = 0.007), while changes were not significant in the non-intervention (non-Int) group (0.13 μg/g, p = 0.95) or the control group (−0.01 μg/g, p = 0.52). UCd in the Int group remained lower than in the non-Int group but higher than in the Control group through the end of follow up. DBP in the Int group decreased significantly from 80 mm Hg at month three (p = 0.03) and stayed around 74 mm Hg for the remainder of the study. SBP also decreased in the Int group but with variations similar to those observed in the other two groups. The two kidney biomarkers showed variations without a clear pattern. Conclusion: This study suggested that UCd reflected both short-term (<3 months) and long-term Cd exposure. In addition, the low-Cd rice intervention showed initial benefits in lowering blood pressure levels, especially DBP, but not kidney biomarkers.

AB - Background: Reducing cadmium (Cd) exposure in Cd-polluted areas in Asia is urgently needed given the toxic effects of Cd. The short-term and long-term benefits of lowering Cd exposure are unknown because of its long half-life in the body. Objectives: We aimed to investigate whether an intervention with low-Cd rice in a contaminated area of China reduced urinary Cd (UCd) levels and improved blood pressure and kidney function outcomes compared to no-intervention in consumers of high-Cd rice in the same region. Methods: 106 non-smoking subjects were divided into three treatment groups: the intervention group (replacing homegrown high-Cd rice with market low-Cd rice, n = 34), the non-intervention group (continue eating high-Cd rice, n = 36) and the control group (continued eating low-Cd rice they have been eating for years, n = 36). The intervention period lasted for almost 8 months, during which participants were visited on up to 4 occasions and UCd, systolic and diastolic blood pressure (SBP, DBP), kidney function biomarkers (β2-microglobulin and N-acetyl-β-D-glucosaminidase) were measured. Results: After 3 months, the geometric mean UCd in the intervention (Int) group decreased significantly by 0.32 μg/g (p = 0.007), while changes were not significant in the non-intervention (non-Int) group (0.13 μg/g, p = 0.95) or the control group (−0.01 μg/g, p = 0.52). UCd in the Int group remained lower than in the non-Int group but higher than in the Control group through the end of follow up. DBP in the Int group decreased significantly from 80 mm Hg at month three (p = 0.03) and stayed around 74 mm Hg for the remainder of the study. SBP also decreased in the Int group but with variations similar to those observed in the other two groups. The two kidney biomarkers showed variations without a clear pattern. Conclusion: This study suggested that UCd reflected both short-term (<3 months) and long-term Cd exposure. In addition, the low-Cd rice intervention showed initial benefits in lowering blood pressure levels, especially DBP, but not kidney biomarkers.

KW - Blood pressure

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KW - Rice

KW - Urinary cadmium

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