An interventional magnetic resonance imaging technique for the molecular characterization of intraprostatic dynamic contrast enhancement

Cynthia Ménard, Robert C. Susil, Peter Choyke, Jonathan Coleman, Robert Grubb, Ahmed Gharib, Axel Krieger, Peter Guion, David Thomasson, Karen Ullman, Sandeep Gupta, Virginia Espina, Lance Liotta, Emanuel Petricoin, Gabor Fitchtinger, Louis L. Whitcomb, Ergin Atalar, C. Norman Coleman, Kevin Camphausen

Research output: Contribution to journalArticle

Abstract

The biological characterization of an individual patient's tumor by noninvasive Imaging will have an important role in cancer care and clinical research if the molecular processes that underlie the image data are known. Spatial heterogeneity in the dynamics of magnetic resonance imaging contrast enhancement (DCE-MRI) is hypothesized to reflect variations in tumor angiogenesis. Here we demonstrate the feasibility of precisely colocalizing DCE-MRI data with the genomic and proteomic profiles of underlying biopsy tissue using a novel MRI-guided biopsy technique in patients with prostate cancer.

Original languageEnglish (US)
Pages (from-to)63-66
Number of pages4
JournalMolecular imaging
Volume4
Issue number1
StatePublished - Dec 1 2005

Keywords

  • Angiogenesis
  • Interventional MRI
  • Micro-array analysis
  • Molecular imaging
  • Prostate cancer

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

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  • Cite this

    Ménard, C., Susil, R. C., Choyke, P., Coleman, J., Grubb, R., Gharib, A., Krieger, A., Guion, P., Thomasson, D., Ullman, K., Gupta, S., Espina, V., Liotta, L., Petricoin, E., Fitchtinger, G., Whitcomb, L. L., Atalar, E., Norman Coleman, C., & Camphausen, K. (2005). An interventional magnetic resonance imaging technique for the molecular characterization of intraprostatic dynamic contrast enhancement. Molecular imaging, 4(1), 63-66.