An intervention to decrease catheter-related bloodstream infections in the ICU

Peter Pronovost, Dale Needham, Sean Berenholtz, David Sinopoli, Haitao Chu, Sara Cosgrove, Bryan Sexton, Robert Hyzy, Robert Welsh, Gary Roth, Joseph Bander, John Kepros, Christine Goeschel

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Catheter-related bloodstream infections occurring in the intensive care unit (ICU) are common, costly, and potentially lethal. METHODS: We conducted a collaborative cohort study predominantly in ICUs in Michigan. An evidence-based intervention was used to reduce the incidence of catheter-related bloodstream infections. Multilevel Poisson regression modeling was used to compare infection rates before, during, and up to 18 months after implementation of the study intervention. Rates of infection per 1000 catheter-days were measured at 3-month intervals, according to the guidelines of the National Nosocomial Infections Surveillance System. RESULTS: A total of 108 ICUs agreed to participate in the study, and 103 reported data. The analysis included 1981 ICU-months of data and 375,757 catheter-days. The median rate of catheter-related bloodstream infection per 1000 catheter-days decreased from 2.7 infections at baseline to 0 at 3 months after implementation of the study intervention (P≤0.002), and the mean rate per 1000 catheter-days decreased from 7.7 at baseline to 1.4 at 16 to 18 months of follow-up (P

Original languageEnglish (US)
Pages (from-to)2725-2732
Number of pages8
JournalNew England Journal of Medicine
Volume355
Issue number26
DOIs
StatePublished - Dec 28 2006

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Catheter-Related Infections
Intensive Care Units
Catheters
Infection
Cross Infection
Cohort Studies
Guidelines
Incidence

ASJC Scopus subject areas

  • Medicine(all)

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An intervention to decrease catheter-related bloodstream infections in the ICU. / Pronovost, Peter; Needham, Dale; Berenholtz, Sean; Sinopoli, David; Chu, Haitao; Cosgrove, Sara; Sexton, Bryan; Hyzy, Robert; Welsh, Robert; Roth, Gary; Bander, Joseph; Kepros, John; Goeschel, Christine.

In: New England Journal of Medicine, Vol. 355, No. 26, 28.12.2006, p. 2725-2732.

Research output: Contribution to journalArticle

Pronovost, P, Needham, D, Berenholtz, S, Sinopoli, D, Chu, H, Cosgrove, S, Sexton, B, Hyzy, R, Welsh, R, Roth, G, Bander, J, Kepros, J & Goeschel, C 2006, 'An intervention to decrease catheter-related bloodstream infections in the ICU', New England Journal of Medicine, vol. 355, no. 26, pp. 2725-2732. https://doi.org/10.1056/NEJMoa061115
Pronovost, Peter ; Needham, Dale ; Berenholtz, Sean ; Sinopoli, David ; Chu, Haitao ; Cosgrove, Sara ; Sexton, Bryan ; Hyzy, Robert ; Welsh, Robert ; Roth, Gary ; Bander, Joseph ; Kepros, John ; Goeschel, Christine. / An intervention to decrease catheter-related bloodstream infections in the ICU. In: New England Journal of Medicine. 2006 ; Vol. 355, No. 26. pp. 2725-2732.
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