An interobserver reproducibility study on invasiveness of bladder cancer using virtual microscopy and heatmaps

Eva Compérat, Lars Egevad, Antonio Lopez-Beltran, Philippe Camparo, Ferran Algaba, Mahul Amin, Jonathan Ira Epstein, Hans Hamberg, Christina Hulsbergen-van de Kaa, Glen Kristiansen, Rodolfo Montironi, Chin Chen Pan, Fabrice Heloir, Kilian Treurniet, Jenna Sykes, Theo H. Van der Kwast

Research output: Contribution to journalArticle

Abstract

Aims: The distinction between non-invasive (pTa) and invasive (pT1) non-muscle invasive bladder cancer (NMIBC) is subject to considerable interobserver variation. We aimed to generate a teaching set of images based on the diagnostic opinions of a panel of expert genitourinary pathologists. Methods and results: Twenty-five transurethral resection specimens initially reported as pT1 NMIBC from two university hospitals were selected on the basis of potential uncertainty of stromal invasion. Digitized slides were reviewed independently by a panel of eight genitourinary pathologists, who annotated any invasive area if present. Annotations were reviewed by the lead panel, and heatmaps of annotated areas were constructed. Reasons for discrepancies were analysed, and kappa scores were calculated to determine agreement among the eight panellists. Full agreement by the eight panellists was obtained in 11 of 25 cases (44%), with a multi-rater (Fleiss) kappa of 0.47 (P <0.0001). After joint review of the seven discordant (agreement

Original languageEnglish (US)
Pages (from-to)756-766
Number of pages11
JournalHistopathology
Volume63
Issue number6
DOIs
StatePublished - Dec 2013

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Urinary Bladder Neoplasms
Microscopy
Observer Variation
Uncertainty
Teaching
Pathologists
Lead

Keywords

  • Bladder cancer
  • Interobserver variation
  • Pathological stage
  • pT1 bladder cancer
  • Virtual microscopy

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

Cite this

Compérat, E., Egevad, L., Lopez-Beltran, A., Camparo, P., Algaba, F., Amin, M., ... Van der Kwast, T. H. (2013). An interobserver reproducibility study on invasiveness of bladder cancer using virtual microscopy and heatmaps. Histopathology, 63(6), 756-766. https://doi.org/10.1111/his.12214

An interobserver reproducibility study on invasiveness of bladder cancer using virtual microscopy and heatmaps. / Compérat, Eva; Egevad, Lars; Lopez-Beltran, Antonio; Camparo, Philippe; Algaba, Ferran; Amin, Mahul; Epstein, Jonathan Ira; Hamberg, Hans; Hulsbergen-van de Kaa, Christina; Kristiansen, Glen; Montironi, Rodolfo; Pan, Chin Chen; Heloir, Fabrice; Treurniet, Kilian; Sykes, Jenna; Van der Kwast, Theo H.

In: Histopathology, Vol. 63, No. 6, 12.2013, p. 756-766.

Research output: Contribution to journalArticle

Compérat, E, Egevad, L, Lopez-Beltran, A, Camparo, P, Algaba, F, Amin, M, Epstein, JI, Hamberg, H, Hulsbergen-van de Kaa, C, Kristiansen, G, Montironi, R, Pan, CC, Heloir, F, Treurniet, K, Sykes, J & Van der Kwast, TH 2013, 'An interobserver reproducibility study on invasiveness of bladder cancer using virtual microscopy and heatmaps', Histopathology, vol. 63, no. 6, pp. 756-766. https://doi.org/10.1111/his.12214
Compérat, Eva ; Egevad, Lars ; Lopez-Beltran, Antonio ; Camparo, Philippe ; Algaba, Ferran ; Amin, Mahul ; Epstein, Jonathan Ira ; Hamberg, Hans ; Hulsbergen-van de Kaa, Christina ; Kristiansen, Glen ; Montironi, Rodolfo ; Pan, Chin Chen ; Heloir, Fabrice ; Treurniet, Kilian ; Sykes, Jenna ; Van der Kwast, Theo H. / An interobserver reproducibility study on invasiveness of bladder cancer using virtual microscopy and heatmaps. In: Histopathology. 2013 ; Vol. 63, No. 6. pp. 756-766.
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