An international study on the use of peroral endoscopic myotomy (POEM) in the management of esophageal diverticula: The first multicenter D-POEM experience

Juliana Yang, Xianhui Zeng, Xianglei Yuan, Kenneth Chang, Omid Sanaei, Lea Fayad, Vivek Kumbhari, Vikesh Singh, Anthony N Kalloo, Bing Hu, Mouen Khashab

Research output: Contribution to journalArticle

Abstract

Background The aim of this study is to report a novel, multicenter experience with the diverticular peroral endoscopic myotomy (D-POEM) technique in the management of esophageal diverticula. Methods This is a multicenter, international, retrospective study involving three centers. D-POEM was performed using the principles of submucosal endoscopy. Results A total of 11 patients with an esophageal diverticulum (Zenker's 7, mid-esophagus 1, epiphrenic 3) were included. The mean size of the esophageal diverticula was 34.5mm. The overall technical success rate of D-POEM was 90.9%, with a mean procedure time of 63.2 minutes. There were no adverse events. Clinical success was achieved in 100% (10/10), with a decrease in mean dysphagia score from 2.7 to 0.1 (P <0.001) during a median follow-up of 145 days (interquartile range 126-273). Conclusion Endoscopic management of esophageal diverticula using the novel technique of D-POEM appears promising. This first case series on D-POEM suggests that the procedure is feasible, safe, and effective in the management of esophageal diverticula. D-POEM offers the distinct advantage of ensuring a complete septotomy. Larger studies are needed to confirm these intriguing results.

Original languageEnglish (US)
Pages (from-to)346-349
Number of pages4
JournalEndoscopy
Volume51
Issue number4
DOIs
StatePublished - Jan 1 2019

Fingerprint

Esophageal Diverticulum
Deglutition Disorders
Esophagus
Endoscopy
Retrospective Studies

ASJC Scopus subject areas

  • Gastroenterology

Cite this

An international study on the use of peroral endoscopic myotomy (POEM) in the management of esophageal diverticula : The first multicenter D-POEM experience. / Yang, Juliana; Zeng, Xianhui; Yuan, Xianglei; Chang, Kenneth; Sanaei, Omid; Fayad, Lea; Kumbhari, Vivek; Singh, Vikesh; Kalloo, Anthony N; Hu, Bing; Khashab, Mouen.

In: Endoscopy, Vol. 51, No. 4, 01.01.2019, p. 346-349.

Research output: Contribution to journalArticle

@article{c85968c3672d4513981a38ef682c115f,
title = "An international study on the use of peroral endoscopic myotomy (POEM) in the management of esophageal diverticula: The first multicenter D-POEM experience",
abstract = "Background The aim of this study is to report a novel, multicenter experience with the diverticular peroral endoscopic myotomy (D-POEM) technique in the management of esophageal diverticula. Methods This is a multicenter, international, retrospective study involving three centers. D-POEM was performed using the principles of submucosal endoscopy. Results A total of 11 patients with an esophageal diverticulum (Zenker's 7, mid-esophagus 1, epiphrenic 3) were included. The mean size of the esophageal diverticula was 34.5mm. The overall technical success rate of D-POEM was 90.9{\%}, with a mean procedure time of 63.2 minutes. There were no adverse events. Clinical success was achieved in 100{\%} (10/10), with a decrease in mean dysphagia score from 2.7 to 0.1 (P <0.001) during a median follow-up of 145 days (interquartile range 126-273). Conclusion Endoscopic management of esophageal diverticula using the novel technique of D-POEM appears promising. This first case series on D-POEM suggests that the procedure is feasible, safe, and effective in the management of esophageal diverticula. D-POEM offers the distinct advantage of ensuring a complete septotomy. Larger studies are needed to confirm these intriguing results.",
author = "Juliana Yang and Xianhui Zeng and Xianglei Yuan and Kenneth Chang and Omid Sanaei and Lea Fayad and Vivek Kumbhari and Vikesh Singh and Kalloo, {Anthony N} and Bing Hu and Mouen Khashab",
year = "2019",
month = "1",
day = "1",
doi = "10.1055/a-0759-1428",
language = "English (US)",
volume = "51",
pages = "346--349",
journal = "Endoscopy",
issn = "0013-726X",
publisher = "Georg Thieme Verlag",
number = "4",

}

TY - JOUR

T1 - An international study on the use of peroral endoscopic myotomy (POEM) in the management of esophageal diverticula

T2 - The first multicenter D-POEM experience

AU - Yang, Juliana

AU - Zeng, Xianhui

AU - Yuan, Xianglei

AU - Chang, Kenneth

AU - Sanaei, Omid

AU - Fayad, Lea

AU - Kumbhari, Vivek

AU - Singh, Vikesh

AU - Kalloo, Anthony N

AU - Hu, Bing

AU - Khashab, Mouen

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background The aim of this study is to report a novel, multicenter experience with the diverticular peroral endoscopic myotomy (D-POEM) technique in the management of esophageal diverticula. Methods This is a multicenter, international, retrospective study involving three centers. D-POEM was performed using the principles of submucosal endoscopy. Results A total of 11 patients with an esophageal diverticulum (Zenker's 7, mid-esophagus 1, epiphrenic 3) were included. The mean size of the esophageal diverticula was 34.5mm. The overall technical success rate of D-POEM was 90.9%, with a mean procedure time of 63.2 minutes. There were no adverse events. Clinical success was achieved in 100% (10/10), with a decrease in mean dysphagia score from 2.7 to 0.1 (P <0.001) during a median follow-up of 145 days (interquartile range 126-273). Conclusion Endoscopic management of esophageal diverticula using the novel technique of D-POEM appears promising. This first case series on D-POEM suggests that the procedure is feasible, safe, and effective in the management of esophageal diverticula. D-POEM offers the distinct advantage of ensuring a complete septotomy. Larger studies are needed to confirm these intriguing results.

AB - Background The aim of this study is to report a novel, multicenter experience with the diverticular peroral endoscopic myotomy (D-POEM) technique in the management of esophageal diverticula. Methods This is a multicenter, international, retrospective study involving three centers. D-POEM was performed using the principles of submucosal endoscopy. Results A total of 11 patients with an esophageal diverticulum (Zenker's 7, mid-esophagus 1, epiphrenic 3) were included. The mean size of the esophageal diverticula was 34.5mm. The overall technical success rate of D-POEM was 90.9%, with a mean procedure time of 63.2 minutes. There were no adverse events. Clinical success was achieved in 100% (10/10), with a decrease in mean dysphagia score from 2.7 to 0.1 (P <0.001) during a median follow-up of 145 days (interquartile range 126-273). Conclusion Endoscopic management of esophageal diverticula using the novel technique of D-POEM appears promising. This first case series on D-POEM suggests that the procedure is feasible, safe, and effective in the management of esophageal diverticula. D-POEM offers the distinct advantage of ensuring a complete septotomy. Larger studies are needed to confirm these intriguing results.

UR - http://www.scopus.com/inward/record.url?scp=85063228787&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063228787&partnerID=8YFLogxK

U2 - 10.1055/a-0759-1428

DO - 10.1055/a-0759-1428

M3 - Article

C2 - 30453378

AN - SCOPUS:85063228787

VL - 51

SP - 346

EP - 349

JO - Endoscopy

JF - Endoscopy

SN - 0013-726X

IS - 4

ER -