An international study on the use of peroral endoscopic myotomy (POEM) in the management of esophageal diverticula: The first multicenter D-POEM experience

Juliana Yang, Xianhui Zeng, Xianglei Yuan, Kenneth Chang, Omid Sanaei, Lea Fayad, Vivek Kumbhari, Vikesh Singh, Anthony N Kalloo, Bing Hu, Mouen Khashab

Research output: Contribution to journalArticle


Background The aim of this study is to report a novel, multicenter experience with the diverticular peroral endoscopic myotomy (D-POEM) technique in the management of esophageal diverticula. Methods This is a multicenter, international, retrospective study involving three centers. D-POEM was performed using the principles of submucosal endoscopy. Results A total of 11 patients with an esophageal diverticulum (Zenker's 7, mid-esophagus 1, epiphrenic 3) were included. The mean size of the esophageal diverticula was 34.5mm. The overall technical success rate of D-POEM was 90.9%, with a mean procedure time of 63.2 minutes. There were no adverse events. Clinical success was achieved in 100% (10/10), with a decrease in mean dysphagia score from 2.7 to 0.1 (P <0.001) during a median follow-up of 145 days (interquartile range 126-273). Conclusion Endoscopic management of esophageal diverticula using the novel technique of D-POEM appears promising. This first case series on D-POEM suggests that the procedure is feasible, safe, and effective in the management of esophageal diverticula. D-POEM offers the distinct advantage of ensuring a complete septotomy. Larger studies are needed to confirm these intriguing results.

Original languageEnglish (US)
Pages (from-to)346-349
Number of pages4
Issue number4
StatePublished - Jan 1 2019


ASJC Scopus subject areas

  • Gastroenterology

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