An integrated tree-based classification approach to prognostic grouping with application to localized melanoma patients

Chen An Tsai, Dung Tsa Chen, James J. Chen, Charles M. Balch, John F. Thompson, Seng Jaw Soong

Research output: Contribution to journalArticlepeer-review

Abstract

We propose an integrated tree-based approach for prognostic grouping of localized melanoma patients. This approach incorporates the survival tree model with the agglomerative hierarchical clustering to group terminal subgroups with similar prognoses together. The Brier score is used to evaluate the goodness of fit and the k-fold cross-validation test is used to evaluate the reproducibility of the scheme for prediction. The proposed approach is applied to an American Joint Committee on Cancer (AJCC) localized melanoma data set and compared with the current AJCC staging system. This approach performs more efficiently than the standard tree methods and has made improvement over the current AJCC melanoma staging system.

Original languageEnglish (US)
Pages (from-to)445-460
Number of pages16
JournalJournal of biopharmaceutical statistics
Volume17
Issue number3
DOIs
StatePublished - May 2007

Keywords

  • Cross-validation
  • Disease staging system
  • Integrated tree-based classification
  • Modified log-rank test

ASJC Scopus subject areas

  • Statistics and Probability
  • Pharmacology
  • Pharmacology (medical)

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