An integrated signal transduction network of macrophage migration inhibitory factor

Tejaswini Subbannayya, Prathyaksha Variar, Jayshree Advani, Bipin Nair, Subramanian Shankar, Harsha Gowda, Sven Saussez, Aditi Chatterjee, T. S.Keshava Prasad

Research output: Contribution to journalArticlepeer-review

Abstract

Macrophage migration inhibitory factor (MIF) is a glycosylated multi-functional protein that acts as an enzyme as well as a cytokine. MIF mediates its actions through a cell surface class II major histocompatibility chaperone, CD74 and co-receptors such as CD44, CXCR2, CXCR4 or CXCR7. MIF has been implicated in the pathogenesis of several acute and chronic inflammatory diseases. Although MIF is a molecule of biomedical importance, a public resource of MIF signaling pathway is currently lacking. In view of this, we carried out detailed data mining and documentation of the signaling events pertaining to MIF from published literature and developed an integrated reaction map of MIF signaling. This resulted in the cataloguing of 68 molecules belonging to MIF signaling pathway, which includes 24 protein-protein interactions, 44 post-translational modifications, 11 protein translocation events and 8 activation/inhibition events. In addition, 65 gene regulation events at the mRNA levels induced by MIF signaling have also been catalogued. This signaling pathway has been integrated into NetPath (http://www.netpath.org), a freely available human signaling pathway resource developed previously by our group. The MIF pathway data is freely available online in various community standard data exchange formats. We expect that data on signaling events and a detailed signaling map of MIF will provide the scientific community with an improved platform to facilitate further molecular as well as biomedical investigations on MIF.

Original languageEnglish (US)
Pages (from-to)165-170
Number of pages6
JournalJournal of Cell Communication and Signaling
Volume10
Issue number2
DOIs
StatePublished - Jun 1 2016

Keywords

  • Immune response
  • Inflammation
  • NetSlim
  • Post-translational modifications
  • Pro-inflammatory cytokine
  • Protein-protein interactions

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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