TY - JOUR
T1 - An integrated signal transduction network of macrophage migration inhibitory factor
AU - Subbannayya, Tejaswini
AU - Variar, Prathyaksha
AU - Advani, Jayshree
AU - Nair, Bipin
AU - Shankar, Subramanian
AU - Gowda, Harsha
AU - Saussez, Sven
AU - Chatterjee, Aditi
AU - Prasad, T. S.Keshava
N1 - Funding Information:
We thank the Department of Biotechnology (DBT), Government of India for research support to the Institute of Bioinformatics. IOB is supported by DBT Program Support on Neuroproteomics and infrastructure for proteomic data analysis (BT/01/COE/08/05). We thank the “Infosys Foundation” for the research support to the Institute of Bioinformatics. HG is a Wellcome Trust/DBT India Alliance Early Career Fellow. JA is a recipient of Senior Research Fellowship from the Council for Scientific and Industrial Research (CSIR), India.
Publisher Copyright:
© 2016, The International CCN Society.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Macrophage migration inhibitory factor (MIF) is a glycosylated multi-functional protein that acts as an enzyme as well as a cytokine. MIF mediates its actions through a cell surface class II major histocompatibility chaperone, CD74 and co-receptors such as CD44, CXCR2, CXCR4 or CXCR7. MIF has been implicated in the pathogenesis of several acute and chronic inflammatory diseases. Although MIF is a molecule of biomedical importance, a public resource of MIF signaling pathway is currently lacking. In view of this, we carried out detailed data mining and documentation of the signaling events pertaining to MIF from published literature and developed an integrated reaction map of MIF signaling. This resulted in the cataloguing of 68 molecules belonging to MIF signaling pathway, which includes 24 protein-protein interactions, 44 post-translational modifications, 11 protein translocation events and 8 activation/inhibition events. In addition, 65 gene regulation events at the mRNA levels induced by MIF signaling have also been catalogued. This signaling pathway has been integrated into NetPath (http://www.netpath.org), a freely available human signaling pathway resource developed previously by our group. The MIF pathway data is freely available online in various community standard data exchange formats. We expect that data on signaling events and a detailed signaling map of MIF will provide the scientific community with an improved platform to facilitate further molecular as well as biomedical investigations on MIF.
AB - Macrophage migration inhibitory factor (MIF) is a glycosylated multi-functional protein that acts as an enzyme as well as a cytokine. MIF mediates its actions through a cell surface class II major histocompatibility chaperone, CD74 and co-receptors such as CD44, CXCR2, CXCR4 or CXCR7. MIF has been implicated in the pathogenesis of several acute and chronic inflammatory diseases. Although MIF is a molecule of biomedical importance, a public resource of MIF signaling pathway is currently lacking. In view of this, we carried out detailed data mining and documentation of the signaling events pertaining to MIF from published literature and developed an integrated reaction map of MIF signaling. This resulted in the cataloguing of 68 molecules belonging to MIF signaling pathway, which includes 24 protein-protein interactions, 44 post-translational modifications, 11 protein translocation events and 8 activation/inhibition events. In addition, 65 gene regulation events at the mRNA levels induced by MIF signaling have also been catalogued. This signaling pathway has been integrated into NetPath (http://www.netpath.org), a freely available human signaling pathway resource developed previously by our group. The MIF pathway data is freely available online in various community standard data exchange formats. We expect that data on signaling events and a detailed signaling map of MIF will provide the scientific community with an improved platform to facilitate further molecular as well as biomedical investigations on MIF.
KW - Immune response
KW - Inflammation
KW - NetSlim
KW - Post-translational modifications
KW - Pro-inflammatory cytokine
KW - Protein-protein interactions
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U2 - 10.1007/s12079-016-0326-x
DO - 10.1007/s12079-016-0326-x
M3 - Article
C2 - 27139435
AN - SCOPUS:84965020793
SN - 1873-9601
VL - 10
SP - 165
EP - 170
JO - Journal of Cell Communication and Signaling
JF - Journal of Cell Communication and Signaling
IS - 2
ER -