An integrated high-resolution physical map of the DPC/BRCA2 region at chromosome 13q12

M. Schutte, E. Rozenblum, C. A. Moskaluk, X. Guan, A. T M S Hoque, S. A. Hahn, Scott E Kern, P. J. De Jong, S. E. Kern

Research output: Contribution to journalArticle

Abstract

We identified a homozygous deletion in a pancreatic carcinoma (DPC) that localized to a 1-cM region at chromosome 13q12.3, which lay within the 6-cM locus of familial breast cancer susceptibility (BRCA2). Here we present a physical map of the region, consisting of YAC, PAC, and cosmid contigs. The YAC contig comprises 16 clones that together span the entire BRCA2 region. The PAC contig comprises 22 clones that together span the DPC region. Seventy cosmid clones were localized within and near the DPC region. Thirty-five sequence-tagged sites were defined and localized within the map. The map indicates the size of the DPC region to be near 250 kb, and provides mapped and tinned resources for the search for the putative tumor suppressor genets) in the region.

Original languageEnglish (US)
Pages (from-to)4570-4574
Number of pages5
JournalCancer Research
Volume55
Issue number20
StatePublished - 1995

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Chromosomes
Cosmids
Clone Cells
Sequence Tagged Sites
Viverridae
Pancreatic Carcinoma
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Schutte, M., Rozenblum, E., Moskaluk, C. A., Guan, X., Hoque, A. T. M. S., Hahn, S. A., ... Kern, S. E. (1995). An integrated high-resolution physical map of the DPC/BRCA2 region at chromosome 13q12. Cancer Research, 55(20), 4570-4574.

An integrated high-resolution physical map of the DPC/BRCA2 region at chromosome 13q12. / Schutte, M.; Rozenblum, E.; Moskaluk, C. A.; Guan, X.; Hoque, A. T M S; Hahn, S. A.; Kern, Scott E; De Jong, P. J.; Kern, S. E.

In: Cancer Research, Vol. 55, No. 20, 1995, p. 4570-4574.

Research output: Contribution to journalArticle

Schutte, M, Rozenblum, E, Moskaluk, CA, Guan, X, Hoque, ATMS, Hahn, SA, Kern, SE, De Jong, PJ & Kern, SE 1995, 'An integrated high-resolution physical map of the DPC/BRCA2 region at chromosome 13q12', Cancer Research, vol. 55, no. 20, pp. 4570-4574.
Schutte M, Rozenblum E, Moskaluk CA, Guan X, Hoque ATMS, Hahn SA et al. An integrated high-resolution physical map of the DPC/BRCA2 region at chromosome 13q12. Cancer Research. 1995;55(20):4570-4574.
Schutte, M. ; Rozenblum, E. ; Moskaluk, C. A. ; Guan, X. ; Hoque, A. T M S ; Hahn, S. A. ; Kern, Scott E ; De Jong, P. J. ; Kern, S. E. / An integrated high-resolution physical map of the DPC/BRCA2 region at chromosome 13q12. In: Cancer Research. 1995 ; Vol. 55, No. 20. pp. 4570-4574.
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AU - Hoque, A. T M S

AU - Hahn, S. A.

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AU - De Jong, P. J.

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