An initial study of neural responses to monetary incentives as related to treatment outcome in cocaine dependence

Zhiru Jia, Patrick D. Worhunsky, Kathleen M. Carroll, Bruce J. Rounsaville, Michael C. Stevens, Godfrey D. Pearlson, Marc N. Potenza

Research output: Contribution to journalArticle

Abstract

Background: Although cocaine dependence (CD) involves abnormalities in drug-related, reward-based decision making, it is not well understood whether these abnormalities generalize to nondrug-related cues and rewards and how neural functions underlying reward processing in cocaine abusers relate to treatment outcome. Methods: Twenty CD patients before treatment and 20 matched healthy control (HC) subjects participated in functional magnetic resonance imaging while performing a monetary incentive delay task. Outcomes through 8 weeks were assessed via percent cocaine-negative urine toxicology, self-reported cocaine abstinence, and treatment retention. Results: Among the whole sample, anticipation of working for monetary reward (i.e., reward anticipation) was associated with activation in the ventral striatum (VS), medial frontal gyrus, thalamus, right subcallosal gyrus, right insula, and left amygdala. Cocaine dependence compared with HC participants exhibited greater activation during notification of rewarding outcome (i.e., reward receipt) in left and right VS, right caudate, and right insula. In CD participants during reward anticipation, activation in left and right thalamus and right caudate correlated negatively with percent cocaine-negative urine toxicology, activation in thalamus bilaterally correlated negatively with self-reported abstinence measures, and activation in left amygdala and parahippocampal gyrus correlated negatively with treatment retention. During reward notification, activation in right thalamus, right VS, and left culmen correlated negatively with abstinence and with urine toxicology. Conclusions: These findings suggest that in treatment-seeking CD participants, corticolimbic reward circuitry is relatively overactivated during monetary incentive delay task performance and specific regional activations related to reward processing may predict aspects of treatment outcome and represent important targets for treatment development in CD.

Original languageEnglish (US)
Pages (from-to)553-560
Number of pages8
JournalBiological Psychiatry
Volume70
Issue number6
DOIs
StatePublished - Sep 15 2011
Externally publishedYes

Fingerprint

Cocaine-Related Disorders
Reward
Motivation
Thalamus
Cocaine
Toxicology
Urine
Amygdala
Healthy Volunteers
Therapeutics
Parahippocampal Gyrus
Task Performance and Analysis
Prefrontal Cortex
Cues
Decision Making
Magnetic Resonance Imaging

Keywords

  • Anticipation
  • cocaine dependence
  • functional magnetic resonance imaging (fMRI)
  • monetary incentive delay task
  • reward circuitry
  • treatment outcome

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Jia, Z., Worhunsky, P. D., Carroll, K. M., Rounsaville, B. J., Stevens, M. C., Pearlson, G. D., & Potenza, M. N. (2011). An initial study of neural responses to monetary incentives as related to treatment outcome in cocaine dependence. Biological Psychiatry, 70(6), 553-560. https://doi.org/10.1016/j.biopsych.2011.05.008

An initial study of neural responses to monetary incentives as related to treatment outcome in cocaine dependence. / Jia, Zhiru; Worhunsky, Patrick D.; Carroll, Kathleen M.; Rounsaville, Bruce J.; Stevens, Michael C.; Pearlson, Godfrey D.; Potenza, Marc N.

In: Biological Psychiatry, Vol. 70, No. 6, 15.09.2011, p. 553-560.

Research output: Contribution to journalArticle

Jia, Z, Worhunsky, PD, Carroll, KM, Rounsaville, BJ, Stevens, MC, Pearlson, GD & Potenza, MN 2011, 'An initial study of neural responses to monetary incentives as related to treatment outcome in cocaine dependence', Biological Psychiatry, vol. 70, no. 6, pp. 553-560. https://doi.org/10.1016/j.biopsych.2011.05.008
Jia, Zhiru ; Worhunsky, Patrick D. ; Carroll, Kathleen M. ; Rounsaville, Bruce J. ; Stevens, Michael C. ; Pearlson, Godfrey D. ; Potenza, Marc N. / An initial study of neural responses to monetary incentives as related to treatment outcome in cocaine dependence. In: Biological Psychiatry. 2011 ; Vol. 70, No. 6. pp. 553-560.
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