An in vivo optical system: Control and monitor cortical activity with improved laser speckle contrast imaging and optogenetics

Nan Li, Galit Pelled, Assaf A. Gilad, Piotr Walczak, Nitish V. Thakor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An integrated optical system combining optogenetics and laser speckle contrast imaging (LSCI) method was explored. For the first time, LSCI was demonstrated capable of revealing the modulated neuronal behavior induced by light activated halorhodopsin a light sensitive chloride pump. Decreased amplitude and extent of both cerebral blood flow response and oxy-hemoglobin concentration response were revealed when halorhodopsin was activated during the electrical forepaw stimulation. The combination of fast transient neuronal manipulation technique-optogenetics with the high spatio-temporal resolution, wide field of view and minimum invasive imaging method LSCI, brings unique insights into studies on basic brain studies, neurovascular coupling and neurological diseases.

Original languageEnglish (US)
Title of host publication2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011
Pages76-79
Number of pages4
DOIs
StatePublished - Jul 20 2011
Event2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011 - Cancun, Mexico
Duration: Apr 27 2011May 1 2011

Publication series

Name2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011

Other

Other2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011
CountryMexico
CityCancun
Period4/27/115/1/11

ASJC Scopus subject areas

  • Neuroscience(all)

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    Li, N., Pelled, G., Gilad, A. A., Walczak, P., & Thakor, N. V. (2011). An in vivo optical system: Control and monitor cortical activity with improved laser speckle contrast imaging and optogenetics. In 2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011 (pp. 76-79). [5910492] (2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011). https://doi.org/10.1109/NER.2011.5910492