An in vivo comparison of hip structure analysis (HSA) with measurements obtained by QCT

K. Ramamurthi, O. Ahmad, K. Engelke, R. H. Taylor, K. Zhu, S. Gustafsson, R. L. Prince, K. E. Wilson

Research output: Research - peer-reviewArticle

Abstract

Summary: In a population of elderly women, bone cross-sectional area (CSA), cross-sectional moment of inertia (CSMI), section modulus (Z), femoral neck axis length (FNAL), and width measured with hip structure analysis (HSA) on dual-energy x-ray absorptiometry (DXA) images in the femoral neck and trochanteric regions are highly correlated to quantitative computed tomography (QCT) measurements. Introduction: HSA is a method of obtaining measurements of proximal femur structure using 2D DXA technology. This study was designed to examine the correlations between HSA measurements and 3D QCT. Methods: Forty-one women (mean age, 82.8 ± 2.5 years) were measured using DXA and a 64-slice CT scanner (1 mm slice thickness, 0.29 mm in plane resolution). HSA parameters were calculated at the narrow neck (NN) and trochanteric (IT) regions on the DXA image. These regions were then translated to anatomically equivalent regions on the QCT dataset by co-registering the DXA image and QCT dataset using four DXA images acquired at different angles. Results: At the NN and IT regions, high linear correlations were measured between HSA and QCT for CSA r = 0.95 and 0.93, CSMI r = 0.94 and 0.93, and Z r = 0.93 and 0.89, respectively. All correlations were highly significant (p <0.001), but there were differences in slope and offset between the two techniques, at least in part due to differences in calibration between the two techniques. FNAL and width of the bone at the NN and IT regions, physical measurements independent of the calibration, were highly correlated (r = 0.90-0.95, p <0.001) and had slopes close to 1.0 (range, 0.978 to 1.003). Conclusion: CSA, CSMI, Z, FNAL, and width measured by HSA correlate highly to high-resolution QCT.

LanguageEnglish (US)
Pages543-551
Number of pages9
JournalOsteoporosis International
Volume23
Issue number2
DOIs
StatePublished - Feb 2012

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Hip
Tomography
X-Rays
Femur Neck
Neck
Calibration
Bone and Bones
Datasets
Femur
Technology
Population

Keywords

  • Bone strength
  • Bone structure
  • DXA
  • Hip structure analysis
  • HSA
  • QCT

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

An in vivo comparison of hip structure analysis (HSA) with measurements obtained by QCT. / Ramamurthi, K.; Ahmad, O.; Engelke, K.; Taylor, R. H.; Zhu, K.; Gustafsson, S.; Prince, R. L.; Wilson, K. E.

In: Osteoporosis International, Vol. 23, No. 2, 02.2012, p. 543-551.

Research output: Research - peer-reviewArticle

Ramamurthi, K, Ahmad, O, Engelke, K, Taylor, RH, Zhu, K, Gustafsson, S, Prince, RL & Wilson, KE 2012, 'An in vivo comparison of hip structure analysis (HSA) with measurements obtained by QCT' Osteoporosis International, vol 23, no. 2, pp. 543-551. DOI: 10.1007/s00198-011-1578-1
Ramamurthi, K. ; Ahmad, O. ; Engelke, K. ; Taylor, R. H. ; Zhu, K. ; Gustafsson, S. ; Prince, R. L. ; Wilson, K. E./ An in vivo comparison of hip structure analysis (HSA) with measurements obtained by QCT. In: Osteoporosis International. 2012 ; Vol. 23, No. 2. pp. 543-551
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abstract = "Summary: In a population of elderly women, bone cross-sectional area (CSA), cross-sectional moment of inertia (CSMI), section modulus (Z), femoral neck axis length (FNAL), and width measured with hip structure analysis (HSA) on dual-energy x-ray absorptiometry (DXA) images in the femoral neck and trochanteric regions are highly correlated to quantitative computed tomography (QCT) measurements. Introduction: HSA is a method of obtaining measurements of proximal femur structure using 2D DXA technology. This study was designed to examine the correlations between HSA measurements and 3D QCT. Methods: Forty-one women (mean age, 82.8 ± 2.5 years) were measured using DXA and a 64-slice CT scanner (1 mm slice thickness, 0.29 mm in plane resolution). HSA parameters were calculated at the narrow neck (NN) and trochanteric (IT) regions on the DXA image. These regions were then translated to anatomically equivalent regions on the QCT dataset by co-registering the DXA image and QCT dataset using four DXA images acquired at different angles. Results: At the NN and IT regions, high linear correlations were measured between HSA and QCT for CSA r = 0.95 and 0.93, CSMI r = 0.94 and 0.93, and Z r = 0.93 and 0.89, respectively. All correlations were highly significant (p <0.001), but there were differences in slope and offset between the two techniques, at least in part due to differences in calibration between the two techniques. FNAL and width of the bone at the NN and IT regions, physical measurements independent of the calibration, were highly correlated (r = 0.90-0.95, p <0.001) and had slopes close to 1.0 (range, 0.978 to 1.003). Conclusion: CSA, CSMI, Z, FNAL, and width measured by HSA correlate highly to high-resolution QCT.",
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AU - Gustafsson,S.

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