An improved synthetic route to huperzine A; New analogues and their inhibition of acetylcholinesterase

Alan P. Kozikowski; Giuseppe Campiani; Patricia Aagaard; Michael McKinney

doi:10.1039/C39930000860

An improved synthetic route to huperzine A; New analogues and their inhibition of acetylcholinesterase

Alan P. Kozikowski, Giuseppe Campiani, Patricia Aagaard, Michael McKinney

School of Medicine

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

A bicycloannulation approach to huperzine A is detailed together with syntheses of the methylene analogue 8, the diamino compound 12 and their inhibition of acetylcholinesterase.

Original language	English (US)
Pages (from-to)	860-862
Number of pages	3
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	10
DOIs	https://doi.org/10.1039/C39930000860
State	Published - Dec 1 1993

ASJC Scopus subject areas

Molecular Medicine

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title = "An improved synthetic route to huperzine A; New analogues and their inhibition of acetylcholinesterase",

abstract = "A bicycloannulation approach to huperzine A is detailed together with syntheses of the methylene analogue 8, the diamino compound 12 and their inhibition of acetylcholinesterase.",

author = "Kozikowski, {Alan P.} and Giuseppe Campiani and Patricia Aagaard and Michael McKinney",

year = "1993",

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doi = "10.1039/C39930000860",

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AU - Kozikowski, Alan P.

AU - Campiani, Giuseppe

AU - Aagaard, Patricia

AU - McKinney, Michael

PY - 1993/12/1

Y1 - 1993/12/1

N2 - A bicycloannulation approach to huperzine A is detailed together with syntheses of the methylene analogue 8, the diamino compound 12 and their inhibition of acetylcholinesterase.

AB - A bicycloannulation approach to huperzine A is detailed together with syntheses of the methylene analogue 8, the diamino compound 12 and their inhibition of acetylcholinesterase.

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U2 - 10.1039/C39930000860

DO - 10.1039/C39930000860

M3 - Article

AN - SCOPUS:0027195976

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JO - Journal of the Chemical Society, Chemical Communications

JF - Journal of the Chemical Society, Chemical Communications

IS - 10

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An improved synthetic route to huperzine A; New analogues and their inhibition of acetylcholinesterase

Abstract

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