An improved synthesis of the radiolabeled prostate-specific membrane antigen inhibitor, [18F]DCFPyL

Hayden T. Ravert, Daniel Holt, Ying Chen, Ronnie Mease, Hong Fan, Martin Gilbert Pomper, Robert F Dannals

Research output: Contribution to journalArticle

Abstract

The radiosynthesis of [18F]DCFPyL on 2 distinct automated platforms with full regulatory compliant quality control specifications is described. The radiotracer synthesis was performed on a custom-made radiofluorination module and the Sofie Biosciences ELIXYS. The radiofluorination module synthesis was accomplished in an average of 66 minutes from end of bombardment with an average specific activity at end of synthesis (EOS) of 4.4 TBq/μmol (120 Ci/μmol) and an average radiochemical yield of 30.9% at EOS. The ELIXYS synthesis was completed in an average of 87 minutes with an average specific activity of 2.2 TBq/μmol (59.3 Ci/μmol) and an average radiochemical yield of 19% at EOS. Both synthesis modules produced large millicurie quantities of [18F]DCFPyL while conforming to all standard US Pharmacopeia Chapter <823> acceptance testing criteria.

Original languageEnglish (US)
Pages (from-to)439-450
Number of pages12
JournalJournal of Labelled Compounds and Radiopharmaceuticals
DOIs
StatePublished - Sep 1 2016

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Keywords

  • fluorine-18
  • molecular imaging
  • prostate imaging
  • radio synthesis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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