An improved synthesis of (3-N-[11C]methyl)spiperone

Robert F. Dannals; Hayden T. Ravert; Alan A. Wilson; Henry N. Wagner

doi:10.1016/0883-2889(86)90100-0

An improved synthesis of (3-N-[¹¹C]methyl)spiperone

Robert F. Dannals, Hayden T. Ravert, Alan A. Wilson, Henry N. Wagner

School of Medicine

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

An improved radiochemical synthesis of (3-N-[¹¹C]methyl) spiperone is reported. The radiotracer was prepared by N-alkylation of spiperone in dimethylformamide in the presence of equimolar aqueous tetrabutylammonium hydroxide and was purified by semi-preparative reversed phase high performance liquid chromatography (C-18 HPLC). The average radiochemical yield was approximately 21% end-of-synthesis (EOS) with an average specific activity of over 2750 mCiμ mol EOS. The total time for synthesis and specific activity determination was approximately 21 min.

Original language	English (US)
Pages (from-to)	433-434
Number of pages	2
Journal	International Journal of Radiation Applications and Instrumentation. Part
Volume	37
Issue number	5
DOIs	https://doi.org/10.1016/0883-2889(86)90100-0
State	Published - 1986

ASJC Scopus subject areas

Radiation
Engineering(all)

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10.1016/0883-2889(86)90100-0

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title = "An improved synthesis of (3-N-[11C]methyl)spiperone",

abstract = "An improved radiochemical synthesis of (3-N-[11C]methyl) spiperone is reported. The radiotracer was prepared by N-alkylation of spiperone in dimethylformamide in the presence of equimolar aqueous tetrabutylammonium hydroxide and was purified by semi-preparative reversed phase high performance liquid chromatography (C-18 HPLC). The average radiochemical yield was approximately 21% end-of-synthesis (EOS) with an average specific activity of over 2750 mCiμ mol EOS. The total time for synthesis and specific activity determination was approximately 21 min.",

author = "Dannals, {Robert F.} and Ravert, {Hayden T.} and Wilson, {Alan A.} and Wagner, {Henry N.}",

note = "Funding Information: AcknoMledRrmfnt.F-This work was supported in part by grant no. NS-15080 from the United States Public Health Service.",

year = "1986",

doi = "10.1016/0883-2889(86)90100-0",

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journal = "Applied Radiation and Isotopes",

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T1 - An improved synthesis of (3-N-[11C]methyl)spiperone

AU - Dannals, Robert F.

AU - Ravert, Hayden T.

AU - Wilson, Alan A.

AU - Wagner, Henry N.

N1 - Funding Information: AcknoMledRrmfnt.F-This work was supported in part by grant no. NS-15080 from the United States Public Health Service.

PY - 1986

Y1 - 1986

N2 - An improved radiochemical synthesis of (3-N-[11C]methyl) spiperone is reported. The radiotracer was prepared by N-alkylation of spiperone in dimethylformamide in the presence of equimolar aqueous tetrabutylammonium hydroxide and was purified by semi-preparative reversed phase high performance liquid chromatography (C-18 HPLC). The average radiochemical yield was approximately 21% end-of-synthesis (EOS) with an average specific activity of over 2750 mCiμ mol EOS. The total time for synthesis and specific activity determination was approximately 21 min.

AB - An improved radiochemical synthesis of (3-N-[11C]methyl) spiperone is reported. The radiotracer was prepared by N-alkylation of spiperone in dimethylformamide in the presence of equimolar aqueous tetrabutylammonium hydroxide and was purified by semi-preparative reversed phase high performance liquid chromatography (C-18 HPLC). The average radiochemical yield was approximately 21% end-of-synthesis (EOS) with an average specific activity of over 2750 mCiμ mol EOS. The total time for synthesis and specific activity determination was approximately 21 min.

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JO - Applied Radiation and Isotopes

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An improved synthesis of (3-N-[¹¹C]methyl)spiperone

Abstract

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