An improved synthesis of (3-N-[11C]methyl)spiperone

Robert F. Dannals, Hayden T. Ravert, Alan A. Wilson, Henry N. Wagner

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


An improved radiochemical synthesis of (3-N-[11C]methyl) spiperone is reported. The radiotracer was prepared by N-alkylation of spiperone in dimethylformamide in the presence of equimolar aqueous tetrabutylammonium hydroxide and was purified by semi-preparative reversed phase high performance liquid chromatography (C-18 HPLC). The average radiochemical yield was approximately 21% end-of-synthesis (EOS) with an average specific activity of over 2750 mCiμ mol EOS. The total time for synthesis and specific activity determination was approximately 21 min.

Original languageEnglish (US)
Pages (from-to)433-434
Number of pages2
JournalInternational Journal of Radiation Applications and Instrumentation. Part
Issue number5
StatePublished - 1986

ASJC Scopus subject areas

  • Radiation
  • Engineering(all)


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