An improved functional neurological examination for use in nonhuman primate studies of focal reperfused cerebral ischemia

William J. Mack, Ryan G. King, Daniel J. Hoh, Alexander Coon, Andrew F. Ducruet, Judy Huang, J. Mocco, Christopher J. Winfree, Anthony L. D'Ambrosio, M. Nathan Nair, Robert R. Sciacca, E. Sander Connolly

Research output: Contribution to journalArticle

Abstract

There is renewed interest in primate models of acute stroke for the evaluation of potential therapeutic agents prior to clinical trials. The development of more precise functional outcome measures would improve the pre-clinical assessment of neuroprotective strategies. We have constructed a grading scale that utilizes an increased number of goal-oriented tasks to assess both behavior and motor function. The new scoring system is designed to enhance precision and accuracy when compared to existing scales. Twenty-seven male baboons were subjected to 1 h of middle cerebral artery territory occlusion followed by reperfusion. Outcome was evaluated using both a standard neurological function scale and a new task-oriented scale. Each scoring system was assessed for reproducibility (inter-observer reliability) and for association with radiographic infarct volume. The task-oriented grading system was significantly less variable than the standard outcome measure (p

Original languageEnglish (US)
Pages (from-to)280-284
Number of pages5
JournalNeurological Research
Volume25
Issue number3
DOIs
StatePublished - Apr 1 2003
Externally publishedYes

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Neurologic Examination
Brain Ischemia
Primates
Outcome Assessment (Health Care)
Papio
Middle Cerebral Artery Infarction
Reperfusion
Stroke
Clinical Trials
Therapeutics

Keywords

  • Baboon
  • Cerebral ischemia
  • Outcome
  • Reperfusion

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

An improved functional neurological examination for use in nonhuman primate studies of focal reperfused cerebral ischemia. / Mack, William J.; King, Ryan G.; Hoh, Daniel J.; Coon, Alexander; Ducruet, Andrew F.; Huang, Judy; Mocco, J.; Winfree, Christopher J.; D'Ambrosio, Anthony L.; Nair, M. Nathan; Sciacca, Robert R.; Connolly, E. Sander.

In: Neurological Research, Vol. 25, No. 3, 01.04.2003, p. 280-284.

Research output: Contribution to journalArticle

Mack, WJ, King, RG, Hoh, DJ, Coon, A, Ducruet, AF, Huang, J, Mocco, J, Winfree, CJ, D'Ambrosio, AL, Nair, MN, Sciacca, RR & Connolly, ES 2003, 'An improved functional neurological examination for use in nonhuman primate studies of focal reperfused cerebral ischemia', Neurological Research, vol. 25, no. 3, pp. 280-284. https://doi.org/10.1179/016164103101201346
Mack, William J. ; King, Ryan G. ; Hoh, Daniel J. ; Coon, Alexander ; Ducruet, Andrew F. ; Huang, Judy ; Mocco, J. ; Winfree, Christopher J. ; D'Ambrosio, Anthony L. ; Nair, M. Nathan ; Sciacca, Robert R. ; Connolly, E. Sander. / An improved functional neurological examination for use in nonhuman primate studies of focal reperfused cerebral ischemia. In: Neurological Research. 2003 ; Vol. 25, No. 3. pp. 280-284.
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