An immunohistochemical study of human postnatal paraganglia associated with the urinary bladder

J. S. Dixon, J. A. Gosling, D. A. Canning, John Phillip Gearhart

Research output: Contribution to journalArticle

Abstract

Histological and immunohistochemical methods were used to study pelvic paraganglia in a series of human postnatal specimens ranging in age from 1 month to 6 y. Up to 5 months of age, many of the encapsulated paraganglia contained small pacinian-like sensory corpuscles which occurred either singly or in small clusters, implying an unknown functional interrelationship during this period. In older specimens, this intimate association was not observed since pacinian corpuscles and small nonencapsulated clusters of paraganglion cells were observed only as separate structures. It is suggested that the paraganglion cells may induce the formation of the pacinian corpuscles during fetal development. Immunohistochemistry using the nerve marker protein gene product (PGP 9.5) demonstrated a rich plexus of varicose nerve fibres within the paraganglia which may directly innervate the paraganglion cells and/or be associated with the profuse vascular supply. A similar density of vasoactive intestinal polypeptide-containing nerves was also demonstrated while some of the nerves contained calcitonin gene related peptide or substance P. The paraganglion cells stained positively for tyrosine hydroxylase, dopamine-β-hydroxylase and neuropeptide Y, but not for phenylethanolamine N-methyltransferase. This combination of immunostaining confirms them as a rich source of noradrenaline.

Original languageEnglish (US)
Pages (from-to)431-436
Number of pages6
JournalJournal of Anatomy
Volume181
Issue number3
StatePublished - 1992
Externally publishedYes

Fingerprint

bladder
Urinary Bladder
Pacinian Corpuscles
nerve tissue
gene
peptide
tyrosine 3-monooxygenase
phenylethanolamine N-methyltransferase
Phenylethanolamine N-Methyltransferase
cells
vasoactive intestinal peptide
neuropeptide Y
substance P
protein
Calcitonin Gene-Related Peptide
Neuropeptide Y
Vasoactive Intestinal Peptide
plexus
fetal development
Tyrosine 3-Monooxygenase

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Anatomy

Cite this

An immunohistochemical study of human postnatal paraganglia associated with the urinary bladder. / Dixon, J. S.; Gosling, J. A.; Canning, D. A.; Gearhart, John Phillip.

In: Journal of Anatomy, Vol. 181, No. 3, 1992, p. 431-436.

Research output: Contribution to journalArticle

Dixon, J. S. ; Gosling, J. A. ; Canning, D. A. ; Gearhart, John Phillip. / An immunohistochemical study of human postnatal paraganglia associated with the urinary bladder. In: Journal of Anatomy. 1992 ; Vol. 181, No. 3. pp. 431-436.
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