TY - JOUR
T1 - An immunoglobulin E-dependent recombinant histamine-releasing factor induces interleukin-4 secretion from human basophils
AU - Schroeder, John T.
AU - Lichtenstein, Lawrence M.
AU - MacDonald, Susan M.
PY - 1996/3/1
Y1 - 1996/3/1
N2 - A novel recombinant histamine-releasing factor (rHFR), which stimulates secretion from a subpopulation of human basophils that express a particular type of immunoglobulin E (IgE) or IgE+, was found to induce interleukin-4 (IL-4) production from cells isolated from these same donors. The secretion of IL-4 protein induced by rHRF significantly correlated with histamine release and the amount of protein generated, and the kinetics were identical to those caused by anti-IgE activation. Furthermore, the ability of rHRF to induce IL-4 protein production from cells not normally responsive to this protein was transferred by passive sensitization with plasma containing IgE+ antibody. That this novel protein stimulates both mediator release and the secretion of IL-4 protein from human basophils suggests a prominent role for this molecule in allergic disease.
AB - A novel recombinant histamine-releasing factor (rHFR), which stimulates secretion from a subpopulation of human basophils that express a particular type of immunoglobulin E (IgE) or IgE+, was found to induce interleukin-4 (IL-4) production from cells isolated from these same donors. The secretion of IL-4 protein induced by rHRF significantly correlated with histamine release and the amount of protein generated, and the kinetics were identical to those caused by anti-IgE activation. Furthermore, the ability of rHRF to induce IL-4 protein production from cells not normally responsive to this protein was transferred by passive sensitization with plasma containing IgE+ antibody. That this novel protein stimulates both mediator release and the secretion of IL-4 protein from human basophils suggests a prominent role for this molecule in allergic disease.
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U2 - 10.1084/jem.183.3.1265
DO - 10.1084/jem.183.3.1265
M3 - Article
C2 - 8642270
AN - SCOPUS:0029923419
SN - 0022-1007
VL - 183
SP - 1265
EP - 1270
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 3
ER -