Abstract
Brain projections to the accessory abducens region and dorsolateral pons were investigated in rabbit using implants of crystalline horseradish peroxidase (HRP). Following implantation of HRP in the accessory abducens region (N = 3), labeled cells were observed in the sensory trigeminal nuclei and other regions implicated in the reflex pathway of the defensive nictitating membrane (NM) response. Neurons in the supratrigeminal zone were also labeled, as were portions of the contralateral red nucleus. Implantation of HRP into the dorsolateral pons (N = 5) revealed ipsilateral projections from deep-cerebellar nuclei in some cases. In addition, the parvocellular reticular formation displayed bilateral labeling of cells and an ipsilateral network of fibers and apparent terminations. Many cells of the contralateral supratrigeminal zone were labeled in these cases. Results were discussed in relation to lesioning and electrophysiological studies implicating the supratrigeminal region and other structures in the control of the classically conditioned NM response. Specifically, the possibility that supratrigeminal neurons are premotor elements responsible for the conditioned response is considered. Alternative hypotheses are discussed, including pathways by which cerebellar nuclei could control conditioned responding.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 747-763 |
| Number of pages | 17 |
| Journal | Brain Research Bulletin |
| Volume | 10 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1983 |
| Externally published | Yes |
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Keywords
- Accessory abducens region
- Brainstem
- Cerebellar nuclei
- Classical conditioning
- Dorsolateral pons
- HRP
- Nictitating membrane response
- Rabbit
- Red Nucleus
- Supratrigeminal region
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
An HRP study of the brainstem afferents to the accessory abducens region and dorsolateral pons in rabbit : Implications for the conditioned nictitating membrane response. / Desmond, John; Rosenfield, Marcy E.; Moore, John W.
In: Brain Research Bulletin, Vol. 10, No. 6, 1983, p. 747-763.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An HRP study of the brainstem afferents to the accessory abducens region and dorsolateral pons in rabbit
T2 - Implications for the conditioned nictitating membrane response
AU - Desmond, John
AU - Rosenfield, Marcy E.
AU - Moore, John W.
PY - 1983
Y1 - 1983
N2 - Brain projections to the accessory abducens region and dorsolateral pons were investigated in rabbit using implants of crystalline horseradish peroxidase (HRP). Following implantation of HRP in the accessory abducens region (N = 3), labeled cells were observed in the sensory trigeminal nuclei and other regions implicated in the reflex pathway of the defensive nictitating membrane (NM) response. Neurons in the supratrigeminal zone were also labeled, as were portions of the contralateral red nucleus. Implantation of HRP into the dorsolateral pons (N = 5) revealed ipsilateral projections from deep-cerebellar nuclei in some cases. In addition, the parvocellular reticular formation displayed bilateral labeling of cells and an ipsilateral network of fibers and apparent terminations. Many cells of the contralateral supratrigeminal zone were labeled in these cases. Results were discussed in relation to lesioning and electrophysiological studies implicating the supratrigeminal region and other structures in the control of the classically conditioned NM response. Specifically, the possibility that supratrigeminal neurons are premotor elements responsible for the conditioned response is considered. Alternative hypotheses are discussed, including pathways by which cerebellar nuclei could control conditioned responding.
AB - Brain projections to the accessory abducens region and dorsolateral pons were investigated in rabbit using implants of crystalline horseradish peroxidase (HRP). Following implantation of HRP in the accessory abducens region (N = 3), labeled cells were observed in the sensory trigeminal nuclei and other regions implicated in the reflex pathway of the defensive nictitating membrane (NM) response. Neurons in the supratrigeminal zone were also labeled, as were portions of the contralateral red nucleus. Implantation of HRP into the dorsolateral pons (N = 5) revealed ipsilateral projections from deep-cerebellar nuclei in some cases. In addition, the parvocellular reticular formation displayed bilateral labeling of cells and an ipsilateral network of fibers and apparent terminations. Many cells of the contralateral supratrigeminal zone were labeled in these cases. Results were discussed in relation to lesioning and electrophysiological studies implicating the supratrigeminal region and other structures in the control of the classically conditioned NM response. Specifically, the possibility that supratrigeminal neurons are premotor elements responsible for the conditioned response is considered. Alternative hypotheses are discussed, including pathways by which cerebellar nuclei could control conditioned responding.
KW - Accessory abducens region
KW - Brainstem
KW - Cerebellar nuclei
KW - Classical conditioning
KW - Dorsolateral pons
KW - HRP
KW - Nictitating membrane response
KW - Rabbit
KW - Red Nucleus
KW - Supratrigeminal region
UR - http://www.scopus.com/inward/record.url?scp=0020959286&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020959286&partnerID=8YFLogxK
U2 - 10.1016/0361-9230(83)90208-3
DO - 10.1016/0361-9230(83)90208-3
M3 - Article
C2 - 6616268
AN - SCOPUS:0020959286
VL - 10
SP - 747
EP - 763
JO - Brain Research Bulletin
JF - Brain Research Bulletin
SN - 0361-9230
IS - 6
ER -