An HphI polymorphism in the E-selectin gene is associated with premature coronary artery disease

F. Zheng, J. A. Chevalier, L. Q. Zhang, D. Virgil, S. Q. Ye, P. O. Kwiterovich

Research output: Contribution to journalArticle

Abstract

An increased expression of E-selectin has been observed in the arterial endothelium interacting with lymphocytes and macrophages in human atherosclerotic lesions. We examined whether a polymorphism in the E-selectin gene, due to a G to T mutation (G98T) in the untranslated region of exon 2, was associated with premature coronary artery disease (CAD). Other lipid and nonlipid risk factors including a Ser to Arg (S128R) substitution in the E-selectin gene were also assessed. In patients with premature CAD (men ≤ 45 years old and women ≤ 55 years old, N = 51) who underwent an elective diagnostic coronary arteriography, the frequency of the mutation was significantly higher than in controls (N = 50, 0.22 vs. 0.10, p = 0.024). After controlling for other CAD risk factors (plasma total cholesterol, triglyceride, LDL-apolipoprotein B, cigarette smoking and the S128R mutation) by multiple logistic analysis, the G98T mutation in the E-selectin gene was still a significant predictor of premature CAD [p = 0.022, odds ratio (95%, CI) = 3.58 (1.20 - 10.67)].

Original languageEnglish (US)
Pages (from-to)58-64
Number of pages7
JournalClinical Genetics
Volume59
Issue number1
DOIs
StatePublished - Jan 24 2001

Keywords

  • Coronary artery disease
  • E-selectin gene
  • Polymorphism

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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    Zheng, F., Chevalier, J. A., Zhang, L. Q., Virgil, D., Ye, S. Q., & Kwiterovich, P. O. (2001). An HphI polymorphism in the E-selectin gene is associated with premature coronary artery disease. Clinical Genetics, 59(1), 58-64. https://doi.org/10.1034/j.1399-0004.2001.590110.x