An fMRI study of multimodal selective attention in schizophrenia

Andrew R. Mayer, Faith M. Hanlon, Terri M. Teshiba, Stefan D. Klimaj, Josef M. Ling, Andrew B. Dodd, Vince D. Calhoun, Juan R. Bustillo, Trent Toulouse

Research output: Contribution to journalArticlepeer-review

Abstract

Background Studies have produced conflicting evidence regarding whether cognitive control deficits in patients with schizophrenia result from dysfunction within the cognitive control network (CCN; top-down) and/or unisensory cortex (bottomup). Aims To investigate CCN and sensory cortex involvement during multisensory cognitive control in patients with schizophrenia. Method Patients with schizophrenia and healthy controls underwent functional magnetic resonance imaging while performing a multisensory Stroop task involving auditory and visual distracters. Results Patients with schizophrenia exhibited an overall pattern of response slowing, and these behavioural deficits were associated with a pattern of patient hyperactivation within auditory, sensorimotor and posterior parietal cortex. In contrast, there were no group differences in functional activation within prefrontal nodes of the CCN, with small effect sizes observed (incongruent-congruent trials). Patients with schizophrenia also failed to upregulate auditory cortex with concomitant increased attentional demands. Conclusions Results suggest a prominent role for dysfunction within auditory, sensorimotor and parietal areas relative to prefrontal CCN nodes during multisensory cognitive control.

Original languageEnglish (US)
JournalBritish Journal of Psychiatry
Volume207
Issue number5
DOIs
StatePublished - Nov 2015

ASJC Scopus subject areas

  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'An fMRI study of multimodal selective attention in schizophrenia'. Together they form a unique fingerprint.

Cite this