An exploratory study of the patients' sleep patterns and inflammatory response following cardiopulmonary bypass (CPB)

Jesus M. Casida, Jean E. Davis, Lavonne Shpakoff, Hossein Yarandi

Research output: Contribution to journalArticlepeer-review

Abstract

Aims and Objectives: To describe sleep patterns and inflammatory response postCPB, determine sleep pattern changes and inflammatory response over time and explore relationships between sleep and biomarkers of stress and inflammation. Background: Despite the numerous citations of the role of sleep in restoration and health maintenance, a paucity of research exists about this phenomenon in patients undergoing CPB. Specifically, there is no research that has explored correlations between sleep patterns and systemic inflammatory response in adult cardiac surgery patients. Design: Exploratory, repeated-measures, correlational study. Method: Subjects were recruited from a Midwestern urban hospital. Of the 25 eligible subjects, 16 males and four females completed the study. Wrist actigraphy was used to measure sleep variables. Salivary cortisol and C-reactive protein (C-RP) levels were measured daily. Data were collected during postoperative nights/days 1 through 4 (T1-T4). Results: Subjects' sleep onset latency (SOL) median scores (0 minute) were within normal range across time periods, whereas median scores for wake after sleep onset (WASO > 270 minutes), sleep fragmentation index (SFI >51%), total sleep time (<153 minutes) and sleep efficiency index (SEI <36%) fell outside the normal ranges. Changes in the median sleep scores over time, however, were not significant at p > 0·05. Median cortisol levels were within normal range (0·3-0·8 μg/dl) from T1-T4, but the C-RP level peaked at T2 (median = 2370 pg/ml). Strong correlations were found: (1) between SFI-cortisol (rs = 0·82), C-RP (rs = 0·65) - WBC (rs = 0·69); (2) between SEI-C-RP (rs = 0·58); (3) between WASO-WBC (rs = 0·48), WASO and cross-clamp time (rs = 0·50); and (4) between SOL-age (rs = -0·55) at p < 0·05. Conclusions: Subjects were severely sleep-deprived with inflammatory response exaggerations warranting further investigations using larger sample sizes. Relevance to clinical practice: This study offers a foundation for developing a conceptual model explaining mechanisms of sleep disturbance and inflammatory response postCPB. This knowledge is crucial for testing sleep-promoting interventions to modulate inflammatory responses essential for preventing complications, and restoring health.

Original languageEnglish (US)
Pages (from-to)2332-2342
Number of pages11
JournalJournal of clinical nursing
Volume23
Issue number15-16
DOIs
StatePublished - Aug 2014

Keywords

  • Adult cardiac surgery
  • Biomarkers
  • Cardiopulmonary bypass
  • Inflammation
  • Sleep patterns
  • Stress

ASJC Scopus subject areas

  • Nursing(all)

Fingerprint Dive into the research topics of 'An exploratory study of the patients' sleep patterns and inflammatory response following cardiopulmonary bypass (CPB)'. Together they form a unique fingerprint.

Cite this