An experimental framework to validate 3D models of cardiac electrophysiology via optical imaging and MRI

Mihaela Pop; Maxime Sermesant; Desmond Chung; Garry Liu; Elliot R. McVeigh; Eugene Crystal; Graham A. Wright

An experimental framework to validate 3D models of cardiac electrophysiology via optical imaging and MRI

Mihaela Pop, Maxime Sermesant, Desmond Chung, Garry Liu, Elliot R. McVeigh, Eugene Crystal, Graham A. Wright

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Our aim is to develop a framework to validate 3-D computer models of cardiac electrophysiology using measurements of action potential obtained via optical imaging (based on voltage-sensitive fluorescence), and heart anatomy and fiber directions which are obtained from magnetic resonance imaging (MRI). In this paper we present preliminary results of this novel framework using a healthy porcine heart ex vivo model and the Aliev & Panfilov mathematical model. This experimental setup will facilitate the testing, validation and adjustment of computational models prior to their integration into clinical applications.

Original language	English (US)
Title of host publication	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Pages	100-109
Number of pages	10
Volume	4466 LNCS
State	Published - 2007
Externally published	Yes
Event	4th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2007 - Salt Lake City, UT, United States Duration: Jun 7 2007 → Jun 9 2007

Other

Other	4th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2007
Country/Territory	United States
City	Salt Lake City, UT
Period	6/7/07 → 6/9/07

Keywords

Computer modelling
Electrophysiology
MRI
Optical imaging

ASJC Scopus subject areas

Computer Science(all)
Biochemistry, Genetics and Molecular Biology(all)
Theoretical Computer Science

Cite this

An experimental framework to validate 3D models of cardiac electrophysiology via optical imaging and MRI. / Pop, Mihaela; Sermesant, Maxime; Chung, Desmond et al.

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 4466 LNCS 2007. p. 100-109.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Pop, M, Sermesant, M, Chung, D, Liu, G, McVeigh, ER, Crystal, E & Wright, GA 2007, An experimental framework to validate 3D models of cardiac electrophysiology via optical imaging and MRI. in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). vol. 4466 LNCS, pp. 100-109, 4th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2007, Salt Lake City, UT, United States, 6/7/07.

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AU - Sermesant, Maxime

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AU - Liu, Garry

AU - McVeigh, Elliot R.

AU - Crystal, Eugene

AU - Wright, Graham A.

PY - 2007

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AB - Our aim is to develop a framework to validate 3-D computer models of cardiac electrophysiology using measurements of action potential obtained via optical imaging (based on voltage-sensitive fluorescence), and heart anatomy and fiber directions which are obtained from magnetic resonance imaging (MRI). In this paper we present preliminary results of this novel framework using a healthy porcine heart ex vivo model and the Aliev & Panfilov mathematical model. This experimental setup will facilitate the testing, validation and adjustment of computational models prior to their integration into clinical applications.

KW - Computer modelling

KW - Electrophysiology

KW - MRI

KW - Optical imaging

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BT - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

T2 - 4th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2007

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ER -

An experimental framework to validate 3D models of cardiac electrophysiology via optical imaging and MRI

Abstract

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Keywords

ASJC Scopus subject areas

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