An exocrine pancreatic stress test with11C-acetate PET and secretin stimulation

Joo Hyun O, Martin A. Lodge, Sanjay Jagannath, Jonathan M. Buscaglia, Yetunde Olagbemiro, Richard L. Wahl

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study was to develop a noninvasive imaging test of pancreatic exocrine function. Methods: In this pilot study, 5 healthy volunteers underwent two 60-min dynamic 11C-acetate PET studies, one before and one after intravenous secretin administration. Kinetic analysis of the pancreas was performed using a 1-compartment model and an image-derived input function. From summed images, standardized uptake values were measured from the pancreas and the liver, and the pancreas-to-liver ratio was computed. Results: The baseline k1 and k2 data for all 5 volunteers were consistent. After secretin stimulation, the k1 and k2 significantly increased (paired t test P = 0.046 and P = 0.023, respectively). In the summed PET images, the pancreas-to-liver ratio decreased (P = 0.037). Increased 11C-acetate activity was observed in the duodenum after secretin stimulation consistent with secretin-induced secretion. Conclusion: 11C-acetate PET studies with secretin stimulation show potential as a noninvasive method for assessing pancreatic exocrine function.

Original languageEnglish (US)
Pages (from-to)1128-1131
Number of pages4
JournalJournal of Nuclear Medicine
Volume55
Issue number7
DOIs
StatePublished - Jul 1 2014

Keywords

  • Pancreas
  • Secretin

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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