An exercise regimen prevents development paclitaxel induced peripheral neuropathy in a mouse model

Jae Sung Park, Sangri Kim, Ahmet Hoke

Research output: Contribution to journalArticle

Abstract

Peripheral neuropathy is a major, dose-limiting complication of many chemotherapeutic agents. Currently there is no effective method to prevent development of chemotherapy-induced peripheral neuropathy (CIPN). Recent studies have shown that exercise can improve regeneration of peripheral nerves but its effect in preventing peripheral neuropathy is unknown. In this study, we examined the effect of a rigorous treadmill exercise program that was started 1week before administration of paclitaxel and continued throughout the study in a mouse model of CIPN. We showed that exercise can partially abrogate features of axonal degeneration induced by paclitaxel including reduction in epidermal nerve fiber density in the plantar hind paw and thermal hypoalgesia. Furthermore, detyrosinated tubulin that is elevated in nerves treated with paclitaxel was normal in exercised animals. This study points to a relatively simple and potentially effective therapeutic option to reduce the neurotoxic effects of chemotherapy.

Original languageEnglish (US)
Pages (from-to)7-14
Number of pages8
JournalJournal of the Peripheral Nervous System
Volume20
Issue number1
DOIs
StatePublished - Mar 1 2015

Keywords

  • exercise
  • neuropathy
  • paclitaxel

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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