TY - JOUR
T1 - An Exclusively Human Milk-Based Diet Is Associated with a Lower Rate of Necrotizing Enterocolitis than a Diet of Human Milk and Bovine Milk-Based Products
AU - Sullivan, Sandra
AU - Schanler, Richard J.
AU - Kim, Jae H.
AU - Patel, Aloka L.
AU - Trawöger, Rudolf
AU - Kiechl-Kohlendorfer, Ursula
AU - Chan, Gary M.
AU - Blanco, Cynthia L.
AU - Abrams, Steven
AU - Cotten, C. Michael
AU - Laroia, Nirupama
AU - Ehrenkranz, Richard A.
AU - Dudell, Golde
AU - Cristofalo, Elizabeth A.
AU - Meier, Paula
AU - Lee, Martin L.
AU - Rechtman, David J.
AU - Lucas, Alan
PY - 2010/4
Y1 - 2010/4
N2 - Objective: To evaluate the health benefits of an exclusively human milk-based diet compared with a diet of both human milk and bovine milk-based products in extremely premature infants. Study design: Infants fed their own mothers' milk were randomized to 1 of 3 study groups. Groups HM100 and HM40 received pasteurized donor human milk-based human milk fortifier when the enteral intake was 100 and 40 mL/kg/d, respectively, and both groups received pasteurized donor human milk if no mother's milk was available. Group BOV received bovine milk-based human milk fortifier when the enteral intake was 100 mL/kg/d and preterm formula if no mother's milk was available. Outcomes included duration of parenteral nutrition, morbidity, and growth. Results: The 3 groups (total n = 207 infants) had similar baseline demographic variables, duration of parenteral nutrition, rates of late-onset sepsis, and growth. The groups receiving an exclusively human milk diet had significantly lower rates of necrotizing enterocolitis (NEC; P = .02) and NEC requiring surgical intervention (P = .007). Conclusions: For extremely premature infants, an exclusively human milk-based diet is associated with significantly lower rates of NEC and surgical NEC when compared with a mother's milk-based diet that also includes bovine milk-based products.
AB - Objective: To evaluate the health benefits of an exclusively human milk-based diet compared with a diet of both human milk and bovine milk-based products in extremely premature infants. Study design: Infants fed their own mothers' milk were randomized to 1 of 3 study groups. Groups HM100 and HM40 received pasteurized donor human milk-based human milk fortifier when the enteral intake was 100 and 40 mL/kg/d, respectively, and both groups received pasteurized donor human milk if no mother's milk was available. Group BOV received bovine milk-based human milk fortifier when the enteral intake was 100 mL/kg/d and preterm formula if no mother's milk was available. Outcomes included duration of parenteral nutrition, morbidity, and growth. Results: The 3 groups (total n = 207 infants) had similar baseline demographic variables, duration of parenteral nutrition, rates of late-onset sepsis, and growth. The groups receiving an exclusively human milk diet had significantly lower rates of necrotizing enterocolitis (NEC; P = .02) and NEC requiring surgical intervention (P = .007). Conclusions: For extremely premature infants, an exclusively human milk-based diet is associated with significantly lower rates of NEC and surgical NEC when compared with a mother's milk-based diet that also includes bovine milk-based products.
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U2 - 10.1016/j.jpeds.2009.10.040
DO - 10.1016/j.jpeds.2009.10.040
M3 - Article
C2 - 20036378
AN - SCOPUS:77949441181
SN - 0022-3476
VL - 156
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 4
ER -