An Exciting Release on TRPM7

Craig Montell

Research output: Contribution to journalArticle

Abstract

Following fusion, synaptic vesicles do not always release all of their neurotransmitter. According to one model, neurotransmitters bind to a charged matrix within secretory vesicles, and release requires entry of counterions. In the current issue of Neuron, Krapivinsky et al. demonstrate that TRPM7 is localized to synaptic vesicles and is required for release of the positively charged neurotransmitter acetylcholine. The results raise the possibility that TRPM7 is the enigmatic channel that supplies counterions for neurotransmitter release.

Original languageEnglish (US)
Pages (from-to)395-397
Number of pages3
JournalNeuron
Volume52
Issue number3
DOIs
StatePublished - Nov 9 2006

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Neurotransmitter Agents
Synaptic Vesicles
Secretory Vesicles
Acetylcholine
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

An Exciting Release on TRPM7. / Montell, Craig.

In: Neuron, Vol. 52, No. 3, 09.11.2006, p. 395-397.

Research output: Contribution to journalArticle

Montell, C 2006, 'An Exciting Release on TRPM7', Neuron, vol. 52, no. 3, pp. 395-397. https://doi.org/10.1016/j.neuron.2006.10.012
Montell, Craig. / An Exciting Release on TRPM7. In: Neuron. 2006 ; Vol. 52, No. 3. pp. 395-397.
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