An examination of the extent of diastereofacial selection in the reactions of a chiral nitrile oxide with achiral alkenes: A route to β-hydroxy carboxylic acids

Alan P. Kozikowski, Yoshinori Kitagawa, James P. Springer

Research output: Contribution to journalArticle


A new synthesis of optically active β-hydroxy carboxylic acids has been developed which is based on the (modest) diastereoselective addition of the chiral nitrile oxide (4) to 1,2-disubstituted alkenes.

Original languageEnglish (US)
Pages (from-to)1460-1462
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number23
StatePublished - Jan 1 1983


ASJC Scopus subject areas

  • Molecular Medicine

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