Abstract
Objective: To reexamine previous findings that reported that blood cells’ membrane potential ratios (MPRs™) differ between youth with ADHD and controls and to determine whether psychostimulants affect MPRs™. Method: Forty-four youth (ages 6-17) with ADHD (not currently taking psychostimulants; n = 24) and controls (n = 20) completed the Mini-International Neuropsychiatric Interview 7 (MINI 7) and a blood draw to determine MPR™. Youth with ADHD provided another blood draw 30 days after receiving psychostimulants. Results: MPR™ values of participants with ADHD who were not taking stimulants were not significantly different from those of the controls. MPR’s™ sensitivity was 79.2% and specificity 25.0%. Among youth with ADHD, there was a trending association between lower MPRs™ and taking stimulants (compared with baseline). Conclusion: Results neither replicate prior findings nor support MPRs’™ utility in diagnosing ADHD in youth. We identified possible MPR™ changes after participants with ADHD began stimulants. Further studies are needed to establish the clinical significance of this finding.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 73-80 |
| Number of pages | 8 |
| Journal | Journal of Attention Disorders |
| Volume | 25 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2021 |
Keywords
- ADD/ADHD
- children
- diagnosis
ASJC Scopus subject areas
- Developmental and Educational Psychology
- Clinical Psychology